| similar : |
APP |
| Alias : |
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; |
| Source : |
HEK293 |
| Species : |
Human |
| Conjugate : |
C-hFc |
| Tag : |
C-hFc |
| Protein length : |
Met1-Leu669 |
| Form : |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Bioactivity : |
Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The IC50 value is < 1.2 nM. |
| MolecularMass : |
The recombinant human APP/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 890 amino acids and predicts a molecular mass of 101 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhAPP/Fc monomer is approximately 150-160 kDa due to the glycosylation. |
| Endotoxin : |
< 1.0 EU per μg of the protein as determined by the LAL method |
| Purity : |
> 95 % as determined by SDS-PAGE |
| Storage : |
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution : |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
| GeneName : |
APP amyloid beta (A4) precursor protein [ Homo sapiens ] |
| GeneNameWeblink : |
351 |
| OfficialSymbol : |
APP |
| OfficialSymbolWeblink : |
351 |
| GeneID : |
351 |
| GeneIDWeblink : |
351 |
| mRNARefseq : |
NM_000484 |
| mRNARefseqWeblink : |
NM_000484.3 |
| ProteinRefseqWeblink : |
NP_000475.1 |
| MIMWeblink : |
104760 |
| UniProtID : |
P05067 |
| UniProtIDWeblink : |
P05067 |
| Synonyms : |
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; |
| MIM : |
104760 |
