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Recombinant Human Intercellular Adhesion Molecule 3, Fc-His

Cat.No. : ICAM3-655H
Product Overview : Recombinant Human intercellular adhesion molecule 3 was produced inHEK293. The extracellular domain (Met1-His485) of human ICAM3 (NP_002153.2) precursor was expressed with the fused C-terminal his-tagged the Fc region of human IgG1 at the C-terminus.
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Cat. No. : ICAM3-655H
Description : The protein ICAM3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting three members. All ICAM proteins are type I transmembrane glycoproteins, and are ligands for leukocyte function-associated antigen 1 (LFA-1) expressed on the surface of all white blood cells. ICAM-3 comprises of five immunoglobulin-like domains, and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule, but also as a potent signalling molecule.ICAM3 is constitutively and abundantly expressed by all leucocytes, and thus is the major ligand for LFA-1 in the initiation of primary immune responses. It has been reported that CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. In addition, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells
Molecular Mass : The recombinant human ICAM3/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 703 amino acids and predicts a molecular mass of 77.2KDa. By SDS-PAGE, the apparent molecular mass of rh ICAM3/Fc is approximately 125-135KDa due to the glycosylation.
Source : Human Cells (HEK293).
Predicted N Terminal : Gln 30.
Endotoxin : <1.0EU per 1μg cytokine as determined by the LAL method.
Formulation : Supplied as a 0.2μm filtered solution of 100mM Glycine, 10mM NaCl, 50mM Tris, pH7.5
Reconstitution : Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Purity : >97%, as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt -70℃.
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Gene Name : ICAM3 intercellular adhesion molecule 3 [ Homo sapiens ]
Synonyms : ICAM3; intercellular adhesion molecule 3; CD50; CDW50; ICAM-R; CDw50; intercellular adhesion molecule-3; Intercellular adhesion molecule 3; ICAM-3; CD50 antigen
Gene ID : 3385
mRNA Refseq : NM_002162
Protein Refseq : NP_002153
MIM : 146631
UniProt ID : P32942
Chromosome Location : 19p13.3-p13.2
Pathway : Cell adhesion molecules (CAMs); Integrin cell surface interactions; Signaling in Immune system
Function : integrin binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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