Mouse Anti-Human ALPP Monoclonal Antibody, PLAP

Cat.No.

CABT-26834MH

Product Overview

Mouse monoclonal antibody to Human ALPP.

Antigen Description

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3 untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.

Clone

IE 22G8

Isotype

IgG2b

Conjugation

PLAP

Immunogen

Tissue / cell preparation. Fresh Hep-2 cells followed by booster injections of fresh Hep-2 cells that had their surface expression of PLAP boosted in culture.

Host

Mouse

Species

Human

Formulation

Liquid

Concentration

Batch dependent within range:0.84 -0.84 mg/ml

Purity Detail

IgG fraction

Applications

ELISA, IHC-Fr, RIA

Storage buffer

Preservative: NoneConstituents: PBS

Storage

Store at +4^oC short term (1-2 weeks). Aliquot and store at -20^oC or -80^oC. Avoid repeated freeze / thaw cycles.

Sequence similarities

Belongs to the alkaline phosphatase family.

Notes

IE 22G8 has potential uses in the diagnosis of ovarian and testicular tumours. The antibody detects both Regan and Nagao isoenzymes.

Antigen Gene Information