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Recombinant Rat Gpt, His tagged

Cat.No. : Gpt-294R
Product Overview : Recombinant Rat Gpt (NP_112301.1) (Met 1-Ser 496), fused with a C-terminal polyhistidine tag, was produced in Baculovirus-Insect cells.
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Source : Baculovirus-Insect Cells
Species : Rat
Tag : His
Form : Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0, 10% glycerol, 0.5mM TCEP
Molecular Mass : The recombinant rat Gpt1 comprises 506 amino acids with a predicted molecular mass of 55 kDa. It migrates as an approximately 48 kDa band in reduced SDS-PAGE.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Publication :
Liver enzyme delayed clearance in rat treated by CSF1 receptor specific antagonist Sotuletinib (2021)
Gene Name : Gpt glutamic-pyruvate transaminase (alanine aminotransferase) [ Rattus norvegicus ]
Official Symbol : Gpt
Gene ID : 81670
mRNA Refseq : NM_031039
Protein Refseq : NP_112301

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What role does the GPT gene, including GPT1 and GPT2 subtypes, play in glucose and amino acid metabolism, and how is it implicated in cancer-related tumorigenesis? 05/01/2022

The GPT gene, encompassing GPT1 and GPT2, is pivotal in glucose and amino acid metabolism. GPT2 is notably linked to tumorigenesis in various cancers, while the involvement of GPT1 in cancer remains uncertain and requires further exploration.

What role does the GPT gene, encoding cytosolic alanine aminotransaminase 1 (ALT1), play in cellular metabolism and liver function? 04/13/2021

The GPT gene encodes ALT1, a key enzyme in cellular metabolism. ALT1 facilitates the reversible transamination between alanine and 2-oxoglutarate, crucial for glucose and amino acid metabolism. Elevated serum ALT1 levels are commonly used as a biomarker for liver injury caused by drug toxicity, infection, alcohol, and steatosis.

How does the combined SMS and GPT signature affect LSCC patient prognosis, and what factors explain the discrepancy between SMS transcriptional and protein levels? 08/04/2020

SMS protein alone doesn't impact LSCC patient prognosis, but when combined with GPT, it shows significance. Inconsistency between SMS transcriptional and protein levels may stem from various factors, including the involvement of regulatory elements and different post-transcriptional and post-translational modifications.

How does GPT gene expression, assessed in LSCC tissues and cell lines, correlate with SMS and impact overall survival rates in LSCC patients? 01/06/2019

Analysis of LSCC tissues and cell lines revealed an inverse relationship between GPT and SMS expressions, confirmed through qRT-PCR and TCGA data. GPT protein, primarily located in the epithelium, was down-regulated in LSCC tissues.

How does GPT gene expression in tissues like skeletal muscle, kidney, and liver reflect cancer-related metabolic changes? 05/12/2018

GPT gene expression serves as a marker for cancer-induced metabolic reprogramming in tissues, indicating shifts in energy metabolism and biosynthetic processes.

Customer Reviews (3)

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Reviews
11/13/2021

    Fantastic customer support. They genuinely care about the success of our research.

    10/11/2020

      Top-notch protein quality! It's our go-to for reliable and reproducible results.

      04/06/2018

        Very happy with this lab product!

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