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Recombinant Human INHBA protein, His-tagged

Cat.No. : INHBA-761H
Product Overview : Recombinant Human INHBA (Ser21-Ser426) protein was fused to His-tag at N-terminus and expressed in human 293 cells (HEK293).
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  • Gene Information
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Description : Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.
Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.
Activin is produced in the gonads, pituitary gland, placenta, and other organs. The bioactivity of Activin A is regulated by a variety of mechanisms. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization; Activin is strongly expressed in wounded skin, and overexpression of activin in epidermis of transgenic mice improves wound healing and enhances scar formation; Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. Activin A increased the expression level of type-I collagen suggesting that activin A acts as a potent activator of fibroblasts; Lack of activin during development results in neural developmental defects.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Ser21
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 13.0 kDa (mature) & 32.0 kDa (pro). As a result of glycosylation and Interchain disulfide bond, the protein migrates as 15 kDa (mature) and 43-48 kDa (pro) unde
Protein length : Ser21-Ser426
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : INHBA
Official Symbol : INHBA
Synonyms : INHBA; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; EDF; FRP
Gene ID : 3624
mRNA Refseq : NM_002192
Protein Refseq : NP_002183
MIM : 147290
UniProt ID : P08476

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which tissues is INHBA predominantly expressed? 06/22/2021

INHBA is often expressed in the ovaries and testes.

What is the role of INHBA in the body? 09/20/2018

INHBA is involved in the regulation of reproductive processes and cell growth.

What is the molecular weight of the INHBA protein? 03/16/2018

The molecular weight is approximately 45 kDa.

Which genes code for the production of INHBA? 11/24/2017

INHBA is encoded by the INHBA gene.

Is INHBA associated with any diseases? 09/08/2017

Mutations in the INHBA gene can be linked to certain reproductive disorders.

What is the full name of the INHBA protein? 09/02/2017

The full name is “Inhibin subunit beta A.”

Does INHBA have any known protein interactions? 08/12/2016

Yes, INHBA can interact with other proteins involved in cell signaling pathways.

Customer Reviews (3)

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Reviews
12/15/2018

    The value derived from the product's usage made the investment worthwhile, considering the insights acquired.

    08/17/2018

      Its reliability over time reduced the need for frequent reordering, saving both time and resources.

      02/24/2017

        The product’s biocompatibility with various cell types and organisms made it versatile for a wide range of applications.

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