| Cat. No. : |
Scarb1-847M |
| Description : |
Scavenger receptor class B, member 1, also known as SCARB1, SRB1 and CD36L1,is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non-placental steroidogenic tissues. It binds high density lipoproteins (LDL) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 is a key component in the reverse cholesterol transport pathway and plays an important role in lipid metabolism. Accordingly, SCARB1 may serve as a useful marker that predicts variation in baseline lipid levels, postprandial lipid response, and response to fenofibrate intervention. The human CD36 and LIMPII analogous-1 (CLA-1) receptor shows high sequence homology with SCARB1, but their functional relationship has not been determined. |
| Molecular Mass : |
The recombinant human SCARB1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 659 amino acids and has a predicted molecular mass of 78 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSCARB1/Fc monomer is approximately 110-115 kDa due to glycosylation. |
| Source : |
Human Cells (HEK293). |
| Predicted N Terminal : |
Pro 33. |
| Endotoxin : |
< 1.0 EU per 1μg cytokine as determined by the LAL method. |
| Formulation : |
Supplied as a 0.2μm filtered solution of PBS, pH7.4. |
| Reconstitution : |
Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
| Purity : |
> 98%, as determined by SDS-PAGE. |
| Stability : |
Samples are stable for up to twelve months from date of receipt -70°C. |
| Storage : |
Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles. |
