|
Cat.No.
|
CABT-28521MH
|
|
Product Overview
|
Mouse monoclonal antibody to Human TPP1.
|
|
Antigen Description
|
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993
|
|
Isotype
|
IgG1
|
|
Immunogen
|
Recombinant fragment, corresponding to amino acids 195-305 of Human TPP1
|
|
Host
|
Mouse
|
|
Species
|
Human
|
|
Formulation
|
Liquid
|
|
Concentration
|
Batch dependent within range:0.50 -1.00 mg/ml
|
|
Purity Detail
|
Protein G purified
|
|
Applications
|
IHC-P, WB
|
|
Storage buffer
|
Preservative: NonePBS, pH 7.2
|
|
Storage
|
Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
|
|
Sequence similarities
|
Belongs to the peptidase S53 family.
|
|
Light chain type
|
kappa
|
|
Antigen Gene Information
|
|
Gene name
|
TPP1 tripeptidyl peptidase I [ Homo sapiens ]
|
|
Official Symbol
|
TPP1
|
|
Synonyms
|
TPP1; tripeptidyl peptidase I; ceroid lipofuscinosis, neuronal 2, late infantile (Jansky Bielschowsky disease) , CLN2; tripeptidyl-peptidase 1; TPP I; Cell growth inhibiting gene 1 protein; Cell growth-inhibiting gene 1 protein; Ceroid lipofuscinosis neuronal 2; Ceroid lipofuscinosis neuronal 2 late infantile (Jansky Bielschowsky disease); Ceroid lipofuscinosis neuronal 2 late infantile; CLN 2; CLN2; GIG 1; GIG1; Growth inhibiting protein 1; LPIC; Lysosomal pepstatin insensitive protease; Lysosomal pepstatin-insensitive protease; MGC21297; TPP 1; TPP I; TPP-1; TPP-I; Tpp1; TPP1_HUMAN; TPPI; Tripeptidyl aminopeptidase; Tripeptidyl peptidase I; Tripeptidyl-peptidase 1; Tripeptidyl-peptidase I; OTTHUMP00000164588; tripeptidyl aminopeptidase; growth-inhibiting protein 1; cell growth-inhibiting gene 1 protein; lysosomal pepstatin insensitive protease; CLN2; GIG1; LPIC; TPP-1;
|
|
GeneID
|
1200
|
|
mRNA Refseq
|
NM_000391
|
|
Protein Refseq
|
NP_000382
|
|
MIM
|
607998
|
|
Uniprot ID
|
O14773
|
|
Chromosome Location
|
11p15.4
|
|
Pathway
|
Activation of Chaperones by IRE1alpha, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Unfolded Protein Response, organism-specific biosystem;
|
|
Function
|
endopeptidase activity; endopeptidase activity; metal ion binding; peptidase activity; peptide binding;
|
|
|
|
Download Datasheet:
|
|