Active Recombinant Human Interferon Gamma Receptor 1

• Cat.No.: IFNGR1-596
• Product Overview: Recombinant Human Interferon Gamma Receptor 1 mRNA (cDNA) obtained from human cells expressed ininsect cells (sf9).

Specification

• Cat. No.: IFNGR1-596H
• Description: The human interferon-gamma receptor complex consists the heterodimer of two chains: IFNGR1 and IFNGR2. In unstimulated cells, these subunits are not preassociated with each other but rather associate through their intracellular domains with inactive forms of specific Janus family kinases ( Jak1 and Jak2). Jak1 and Jak2 constitutively associate with IFNGR1 and IFNGR2, respectively. Binding of IFN-γ to IFNGR1 induces the rapid dimerization of IFNGR1 chains, thereby forming a site that is recognized by the extracellular domain of IFNGR2. The ligand-induced assembly of the complete receptor complex contains two IFNGR1 and two IFNGR2 subunits which bring into close juxtaposition the intracellular domains of these proteins together with the inactive Jak1 and Jak2 kinases that they associate with. In this complex, Jak1 and Jak2 transactivate one another and then phosphorylate IFNGR1, thereby forming a paired set of Stat1 docking sites on the ligated receptor.
• Source: Insect cells (sf9).
• Bioactivity: Binds human interferon gamma.
• Purity: > 95%, as determined by SDS-PAGE.
• Shipping Temperature: Ice Pack.
• Physical State Of Product During Shipping: Frozen.

Gene Information

• Gene Name: IFNGR1 interferon gamma receptor 1 [ Homo sapiens ]
• Synonyms: IFNGR1; interferon gamma receptor 1; CD119; IFNGR; FLJ45734; AVP, type 2; CD119 antigen; immune interferon receptor 1; interferon-gamma receptor alpha chain; IFN-gamma-R1; OTTHUMP00000017285; interferon gamma receptor 1
• Gene ID: 3459
• mRNA Refseq: NM_000416
• Protein Refseq: NP_000407
• MIM: 107470
• UniProt ID: P15260
• Chromosome Location: 6q23-q24
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity
• Function: cytokine binding; interferon-gamma receptor activity; receptor activity