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Recombinant Human Trefoil Factor 2

Cat.No. : TFF2-659H
Product Overview : Recombinant human TFF2 is a 12.0 kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds. It was expressed inE. Coli.
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Cat. No. : TFF2-659H
Description : The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma.
Source : Escherichia Coli.
Amino Acid Sequence : EKPSPCQCSR LSPHNRTNCG FPGITSDQCF DNGCCFDSSVTGVPWCFHPL PKQESDQCVM EVSDRRNCGY PGISPEECASRKCCFSNFIF EVPWCFFPKS VEDCHY.
Supplied : Lyophilized powder with no additives.
Purity : >98% by SDS-Page and HPLC analysis. Endotoxin level is less than 0.1ng per ug (1EU/ug) of protein.
Reconstitution : Lyophilized TFF2 should be reconstituted in water to a concentration of 0.1-1mg/ml. Allow to set at least 30 minutes at 4°C, mix well. If desired, tighten cap and centrifuge for 1 minute at 1000rpm to concentrate material in vial. This solution can be diluted into other buffered solutions or stored at 4°C for up to 1 week or at -20°C for future use.
Note : If this material is not to be used for coating or labeling (or other applications requiring carrier free material), the addition of 0.1% BSA or HSA to any further dilution buffers or dilution in sterile culture media is recommended to enhance stability and minimize absorption to vial. Ideally, maintain stock >20ug/ml.
Reactivity : Determined by its ability to chemoattract human monocytes using a concentration of 1-10.0ng/ml.
Storage : The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20°C. Reconstituted TFF2 should be stored in working aliquots at -20°C. avoid frequent freeze thaw cycles.
Gene Name : TFF2 trefoil factor 2 [ Homo sapiens ]
Synonyms : trefoil factor 2; SP; SML1; TFF2; spasmolysin; spasmolytic protein 1; spasmolytic polypeptide; SP; Spasmolysin; Spasmolytic polypeptide; trefoil factor 2, SML1, human spasmolytic polypeptide (SP)
Gene ID : 7032
mRNA Refseq : NM_005423
Protein Refseq : NP_005414
MIM : 182590
UniProt ID : Q03403
Chromosome Location : 21q22.3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does TFF2 protein contribute to the protection of the gastric mucosa? 02/15/2022

TFF2 promotes the formation of a protective mucous layer on the stomach lining, preventing damage from stomach acid and other harmful factors.

Can TFF2 protein be administered orally for clinical applications? 10/17/2020

Researchers are exploring various methods of delivering TFF2 protein, including oral administration, to treat gastrointestinal conditions.

In what ways is TFF2 protein being studied for potential therapeutic applications in IBD? 03/17/2019

TFF2 is being investigated for its potential to reduce inflammation and promote mucosal healing in IBD patients.

Are there ongoing clinical trials or research investigating the therapeutic potential of TFF2 protein? 03/10/2017

Yes, there are ongoing studies exploring the use of TFF2 protein in the treatment of various gastrointestinal disorders.

How does TFF2 protein compare to other treatments for gastric ulcers or IBD? 11/03/2016

TFF2 protein-based therapies may offer an alternative or complementary approach to traditional treatments for these conditions.

Customer Reviews (3)

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Reviews
03/14/2020

    The manufacturer's technical support can also aid researchers in the data analysis phase.

    12/17/2018

      the manufacturer's technical support is instrumental in assisting researchers throughout their trials.

      04/15/2016

        They can provide valuable guidance in experimental design, optimization, and troubleshooting, helping researchers overcome challenges and maximize the efficiency of their trials.

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