Recombinant Porcine Interleukin-8
Cat.No. : | IL8-195P |
Product Overview : | Recombinant Porcine Interleukin-8 produced inE.Coliwas a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8291 Dalton. |
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Cat. No. : | IL8-195P |
Description : | Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages that phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor. |
Source : | Escherichia Coli. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Biological Activity : | The biological activity of IL8 was determined by the dose dependent mobilization of intracellular calcium (calcium flux) with human neutrophils and was found to be >1.0 ng/mL. |
Formulation : | Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. |
Protein Content : | Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 0.638 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IL-8 as a Reference Standard. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Solubility : | It is recommended to reconstitute the lyophilized Interleukin 8 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Stability : | Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution CXCL8 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. |
Storage : | The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
Gene Name : | IL8 interleukin 8 [ Sus scrofa ] |
Synonyms : | IL8; interleukin 8; alveolar macrophage-derived chemotactic factor-I; CXCL8; AMCF-I |
Gene ID : | 396880 |
mRNA Refseq : | NM_213867 |
Protein Refseq : | NP_999032 |
UniProt ID : | P26894 |
Pathway : | Bladder cancer; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Pathways in cancer; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway |
Products Types
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IL8-191P | Recombinant Porcine IL8 Protein | +Inquiry |
IL8-4401Z | Recombinant Zebrafish IL8 Protein | +Inquiry |
◆ Lysates | ||
IL8-3004HCL | Recombinant Human IL8 cell lysate | +Inquiry |
IL8-3002HCL | Recombinant Human IL8 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionActs as a chemical messenger in the immune system that regulates inflammation and attracts immune cells such as white blood cells.
Regulating tumor microenvironment, promoting tumor growth and metastasis, and can be used in tumor therapy research.
IL8 plays a role in regulating and promoting the migration and activation of inflammatory cells in the inflammatory response.
Can be used to treat inflammatory diseases (such as rheumatoid arthritis, psoriasis), tumors (such as lung cancer, breast cancer) and other diseases.
Yes, IL8 is closely related to immunotherapy, which can enhance the role of the immune system and assist in the treatment of certain diseases.
IL8 is generally prepared by gene recombination technology, and the IL8 gene is introduced into the appropriate expression system, and then expressed and purified.
Customer Reviews (3)
Write a reviewIL8 has good fluorescence and absorption properties.
NIPBL has good stability in different environments and is not easy to degrade.
Through animal models or in vitro experiments to evaluate the mechanism of the recombinant protein in related diseases, we found that the effect is very good.
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