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Recombinant Porcine Interleukin-8

Cat.No. : IL8-195P
Product Overview : Recombinant Porcine Interleukin-8 produced inE.Coliwas a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8291 Dalton.
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  • Gene Information
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Cat. No. : IL8-195P
Description : Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages that phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Biological Activity : The biological activity of IL8 was determined by the dose dependent mobilization of intracellular calcium (calcium flux) with human neutrophils and was found to be >1.0 ng/mL.
Formulation : Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Protein Content : Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 0.638 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IL-8 as a Reference Standard.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Solubility : It is recommended to reconstitute the lyophilized Interleukin 8 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability : Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution CXCL8 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Storage : The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Gene Name : IL8 interleukin 8 [ Sus scrofa ]
Synonyms : IL8; interleukin 8; alveolar macrophage-derived chemotactic factor-I; CXCL8; AMCF-I
Gene ID : 396880
mRNA Refseq : NM_213867
Protein Refseq : NP_999032
UniProt ID : P26894
Pathway : Bladder cancer; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Pathways in cancer; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of IL8 in the immune system? 08/31/2021

Acts as a chemical messenger in the immune system that regulates inflammation and attracts immune cells such as white blood cells.

How about the effect of IL8 on tumor? 06/01/2020

Regulating tumor microenvironment, promoting tumor growth and metastasis, and can be used in tumor therapy research.

What is the relationship between IL8 and inflammatory response? 01/18/2020

IL8 plays a role in regulating and promoting the migration and activation of inflammatory cells in the inflammatory response.

Which diseases can be treated with IL8? 12/02/2019

Can be used to treat inflammatory diseases (such as rheumatoid arthritis, psoriasis), tumors (such as lung cancer, breast cancer) and other diseases.

Is IL8 relevant to immunotherapy? 03/18/2019

Yes, IL8 is closely related to immunotherapy, which can enhance the role of the immune system and assist in the treatment of certain diseases.

By what method is IL8 generally prepared? 02/03/2019

IL8 is generally prepared by gene recombination technology, and the IL8 gene is introduced into the appropriate expression system, and then expressed and purified.

Customer Reviews (3)

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Reviews
10/28/2022

    IL8 has good fluorescence and absorption properties.

    11/29/2020

      NIPBL has good stability in different environments and is not easy to degrade.

      04/17/2019

        Through animal models or in vitro experiments to evaluate the mechanism of the recombinant protein in related diseases, we found that the effect is very good.

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