Recombinant Murine Interleukin 12b

• Cat.No.: Il12b-178M
• Product Overview: Recombinant Murine Interleukin 12b produced inCHOwas a 40.0kDa protein containing 313 amino acid residues.

Specification

• Cat. No.: Il12b-178M
• Description: Interleukin-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23. Additionally, p40 can associate itself through disulfide linkage to form a dimer that acts as a potent IL12 antagonist.
• Source: E.coli.
• Purity: >95% (SDS-PAGE; HPLC).
• Endotoxin Level: <0.1ng per μg of IL-12p40.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biologically Activity: Test in progress.
• Reconstitution: The murine IL-12p40 should be reconstituted in water to a concentration of 0.1-1.0mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted murine IL12p40 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Il12b interleukin 12b [ Mus musculus ]
• Synonyms: Il12b; interleukin 12b; p40; Il-12b; Il12p40; Il-12p40; IL-12 p40; IL-23 subunit p40; OTTMUSP00000005619
• Gene ID: 16160
• mRNA Refseq: NM_008352
• Protein Refseq: NP_032378
• UniProt ID: P43432
• Chromosome Location: 11
• Pathway: Allograft rejection; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus
• Function: cytokine activity; cytokine receptor activity; interleukin-12 alpha subunit binding; protein homodimerization activity