Recombinant Human BMPR1A, His-tagged
Cat.No. : | BMPR1A-160H |
Product Overview : | Recombinant BMPR1A produced ininsect cellswas a 23kDa protein It consisted an extracellular domain that was fused with a carboxy-terminal 6X his-tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | BMPR1A-160H |
Description : | The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor 1A (BMPR-1A), also known as activin receptor-like kinase (ALK)-3, is a one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-b family cytokines. In contrast to the TGF-b receptor system in which the type I receptor does not bind TGF-b in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPR-IA, BMPR-IB/ALK-6, and ActR-I/ALK-2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPR-IA binds BMP-2 and -4 with high-affinity in solution and is a potent BMP-2/4 antagonist in vitro. |
Source : | Insect cells. |
Purity : | >90% by SDS-PAGE and silver staining. |
Endotoxin level : | <0.1ng per μg of BMPRIA. |
Buffer : | PBS. |
Stabilizer : | None. |
Formulation : | Lyophilized. |
Biologically Activity : | Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 1-3 μg/ml in the presence of 500 ng/ml of recombinant human BMP-2. |
Reconstitution : | It is recommended that sterile PBS containing at least 0.1% HSA or BSA be added to the vial to prepare a stock solution of no less than 100 μg/ml of BMPR-IA. |
Stability : | Lyophilized samples are stable for greater than six month at -20°C to -70°C. Upon reconstitution, this cytokine can be stored under sterile conditions at -2°C to -4°C for one month or at -20°C to -70°C for three month without detecable loss of activity. Avoid repeated freeze–thaw cyles. |
Gene Name : | BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ] |
Synonyms : | BMPR1A; bone morphogenetic protein receptor, type IA; ALK3; SKR5; CD292; ACVRLK3; 10q23del; OTTHUMP00000020014; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor; Bone morphogenetic protein receptor type-1A; EC 2.7.11.30; Serine/threonine-protein kinase receptor R5; Activin receptor-like kinase 3; ALK-3 |
Gene ID : | 657 |
mRNA Refseq : | NM_004329 |
Protein Refseq : | NP_004320 |
MIM : | 601299 |
UniProt ID : | P36894 |
Chromosome Location : | 10q22.3 |
Pathway : | Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP |
Function : | ATP binding; SMAD binding; magnesium ion binding; nucleotide binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta receptor activity |
Products Types
◆ Recombinant Protein | ||
BMPR1A-657R | Recombinant Rat BMPR1A Protein, His (Fc)-Avi-tagged | +Inquiry |
BMPR1A-1043C | Active Recombinant Canine BMPR1A protein(Met1-Arg152), hFc-tagged | +Inquiry |
BMPR1A-169H | Recombinant Human BMPR1A Protein, His (Fc)-Avi-tagged | +Inquiry |
BMPR1A-361H | Recombinant Human BMPR1A Protein (177-532 aa), His-SUMO-tagged | +Inquiry |
BMPR1A-0787H | Recombinant Human BMPR1A Protein (M1-I532), Tag Free | +Inquiry |
◆ Lysates | ||
BMPR1A-2466MCL | Recombinant Mouse BMPR1A cell lysate | +Inquiry |
BMPR1A-2145HCL | Recombinant Human BMPR1A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionAbnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.
The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.
Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.
Customer Reviews (3)
Write a reviewThe enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.
When experimenting with this protein, stable and repeatable results can be obtained.
This product has strict quality control and complies with relevant industry standards.
Ask a Question for All BMPR1A Products
Required fields are marked with *
My Review for All BMPR1A Products
Required fields are marked with *
Inquiry Basket