Recombinant Human Interleukin 6 Receptor
Cat.No. : | IL6R-964H |
Product Overview : | Recombinant human sIL-6R produced inE.coliis a 37.6 kDa protein consisting of the extracellular domain of the IL-6R alpha chain (338 amino acid residues). |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL6R-964H |
Description : | IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. The IL-6R alpha chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6R alpha. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6R alpha alone. IL-6R alpha is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6R alpha which consists of only the extracellular domain of the IL-6R alpha chain, acts as an agonist of IL-6 activity at low concentrations. |
Source : | E.coli. |
Purity : | > 98% by SDS-PAGE and HPLC analysis. |
Endotoxin Level : | < 0.1 ng per ug of sIL-6 receptor. |
Stabilizer : | None. |
Formulation : | Lyophilized. |
Biological Activity : | The ED50 was determined by it"s ability to intensify the IL-6 induced growth inhibition of murine M1 cells is < 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6. |
Reconstitution : | We recommended a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at 4℃ for one week or at –20℃ for future use. |
Stability : | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20℃. Reconstituted human sIL-6R should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles. |
Gene Name : | IL6R interleukin 6 receptor [ Homo sapiens ] |
Synonyms : | IL6R; interleukin 6 receptor; CD126; IL-6R-1; IL6R-alpha; IL-6R-alpha; IL6RA; MGC104991; OTTHUMP00000034320; gp80; CD126 antigen; IL-6R 1; Interleukin-6 receptor alpha chain precursor; B cell stimulatory factor-2; Membrane glycoprotein 80; interleukin 6 receptor alpha subunit |
Gene ID : | 3570 |
mRNA Refseq : | NM_000565 |
Protein Refseq : | NP_000556 |
MIM : | 147880 |
UniProt ID : | P08887 |
Chromosome Location : | 1q21 |
Pathway : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage |
Function : | ciliary neurotrophic factor binding; ciliary neurotrophic factor receptor activity;enzyme binding; interleukin-6 receptor activity; protein homodimerization activity; receptor binding |
Products Types
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IL6R-1058H | Recombinant Human IL-6 Protein | +Inquiry |
IL6R-1054H | Recombinant Human IL6R Protein, His-tagged | +Inquiry |
IL6R-213H | Recombinant Human IL6R Protein (ECD), His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
IL6R-2903HCL | Recombinant Human IL6R cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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