Recombinant Human Trefoil Factor 3

• Cat.No.: TFF3-973H
• Product Overview: Recombinant human TFF3 produced inE.coliis a 13.2 kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

Specification

• Cat. No.: TFF3-973H
• Description: The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.
• Source: E.coli.
• Purity: > 98% by SDS-PAGE analyses.
• Endotoxin Level: < 0.1 ng per ug of TFF-3.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 μg/ml.
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted TFF-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at-20℃. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: TFF3 trefoil factor 3 (intestinal) [ Homo sapiens ]
• Synonyms: TFF3; trefoil factor 3 (intestinal); ITF; TFI; HITF; hP1.B; Intestinal trefoil factor; Polypeptide P1.B; secretory protein; trefoil factor 3; trefoil factor 3, HITF, human intestinal trefoil factor; Trefoil factor 3
• Gene ID: 7033
• mRNA Refseq: NM_003226
• Protein Refseq: NP_003217
• MIM: 600633
• UniProt ID: Q07654
• Chromosome Location: 21q22.3
• Function: chromatin binding; protein binding; sequence-specific DNA binding; transcription factor activity