Coactosin-like protein
Cat.No. : | CBCRY15 |
- Specification
- Gene Information
- Related Products
Cat. No. : | CBCRY15 |
Background : | Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulating the activities of actin and 5-Lipoxygenase. Coactosin counteracts the capping activity of capping protein which inhibits the actin polymerization. The structure showed a high level of similarity to ADF-H domain, although their amino acid sequences share low degree of homology. A few conserved hydrophobic residues that may contribute to the folding were identified. This structure suggests coactosin-like protein bind to F-actin in a different way from ADF/Cofilin family. Combined with the information from previous mutagenesis studies, the binding sites for F-actin and 5-Lipoxygenase were analyzed, respectively. These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously. |
Protein Classification : | protein binding |
Structure Weight : | 31763.60 Da |
Polymer : | 1 |
Molecule : | Coactosin-like protein |
Chain Length : | 145 amino acids |
PDB ID : | 1T2L |
MMDB ID : | 30298 |
Source : | E.coli |
Method : | X-Ray Diffraction |
Resolution : | 2.8 Å |
Reference : | Liu, L., Wei, Z., Wang, Y., Wan, M., Cheng, Z., Gong, W.(2004) Crystal Structure of Human Coactosin-like ProteinJ.Mol.Biol.344: 317-323 |
Gene Name : | COTL1 |
Synonyms : | CLP; FLJ43657; MGC19733; coactosin-like 1; coactosin-like 1 (Dictyostelium) |
UniProt ID : | Q14019 |
Gene ID : | 23406 |
Chromosome Location : | 16q24.1 |
Function : | actin binding; protein binding |
Products Types
◆ Recombinant Protein | ||
COTL1-1730H | Recombinant Human COTL1 Protein, GST-tagged | +Inquiry |
COTL1-1206R | Recombinant Rat COTL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Cotl1-2276M | Recombinant Mouse Cotl1 Protein, Myc/DDK-tagged | +Inquiry |
COTL1-804R | Recombinant Rhesus Macaque COTL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
COTL1-2721H | Recombinant Human COTL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
COTL1-7338HCL | Recombinant Human COTL1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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