Recombinant Human Growth Differentiation Factor 11
Cat.No. : | GDF11-242 |
Product Overview : | Recombinant human GDF-11 produced inE.coliis a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. |
- Specification
- Gene Information
- Related Products
Cat. No. : | GDF11-242 |
Description : | GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. |
Source : | E.coli. |
Purity : | > 98% by SDS-PAGE and HPLC analysis. |
Endotoxin level : | < 0.1 ng per μg of Galectin-1. |
Stabilizer : | None. |
Formulation : | Lyophilized. |
Biologically Activity : | The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 μg/ml. |
Reconstitution : | The human GDF-11 should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at 4°Cfor one week or -20°Cfor future use. |
Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted GDF-11 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze-thaw cycles. |
Gene Name : | GDF11 growth differentiation factor 11 [ Homo sapiens ] |
Synonyms : | GDF11; growth differentiation factor 11; BMP11; BMP-11; bone morphogenetic protein 11; GDF-11 |
Gene ID : | 10220 |
mRNA Refseq : | NM_005811 |
Protein Refseq : | NP_005802 |
MIM : | 603936 |
UniProt ID : | O95390 |
Chromosome Location : | 12q13.13 |
Function : | cytokine activity; growth factor activity; protein binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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