Recombinant Human Growth Differentiation Factor 15
Cat.No. : | GDF15-243H |
Product Overview : | Recombinant Human GDF-15/MIC-1 produced inCell cultureis a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains. |
- Specification
- Gene Information
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Cat. No. : | GDF15-243H |
Description : | GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. |
Source : | Cell culture. |
Purity : | 98 % (SDS-PAGE, HPLC). |
Endotoxin level : | < 0.1 ng per μg of GDF-15/MIC-1. |
Stabilizer : | None. |
Formulation : | Lyophilized. |
Biologically Activity : | Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 μg/ml. |
Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted GDF-15/MIC-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles. |
Gene Name : | GDF15 growth differentiation factor 15 [ Homo sapiens ] |
Synonyms : | GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1;NAG-1; PTGFB; GDF-15; PTGF-beta; prostate differentiation factor; NSAID(nonsteroidal anti-inflammatory drug)-activatedprotein 1; NRG-1; Macrophage inhibitory cytokine 1; NSAID-activated gene1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placentalbone morphogeneticprotein;Growth/differentiation factor 15 |
Gene ID : | 9518 |
mRNA Refseq : | NM_004864 |
Protein Refseq : | NP_004855 |
MIM : | 605312 |
UniProt ID : | Q99988 |
Chromosome Location : | 19p13.11 |
Function : | cytokine activity; growth factor activity |
Products Types
◆ Recombinant Protein | ||
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GDF15-284H | Recombinant Human GDF15 protein, His-tagged | +Inquiry |
GDF15-2158R | Recombinant Rat GDF15 Protein, His (Fc)-Avi-tagged | +Inquiry |
GDF15-4821H | Active Recombinant Human GDF15 Protein | +Inquiry |
GDF15-17H | Recombinant Human GDF15 Protein | +Inquiry |
◆ Native Protein | ||
GDF15-27680TH | Active Native Human GDF15 Protein | +Inquiry |
◆ Lysates | ||
GDF15-2705HCL | Recombinant Human GDF15 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGDF15 influences cardiovascular health, impacting heart failure progression and atherosclerotic processes.
GDF15 modulates inflammatory and immune responses, crucial in the context of chronic diseases.
GDF15 contributes to tissue repair and fibrosis, particularly in liver and kidney pathologies.
GDF15 affects cancer development by altering the tumor microenvironment and influencing tumor cell behavior.
Changes in GDF15 expression are linked to aging and age-related diseases, affecting various physiological processes.
GDF15 is involved in regulating energy metabolism and appetite, playing a key role in obesity and metabolic syndromes.
GDF15 is involved in cellular stress responses, influencing apoptosis and cell survival mechanisms.
Customer Reviews (3)
Write a reviewDependable protein purification, consistent and cost-effective.
Precise mass spectrometry analysis, key for proteomics research.
Great antibody validation, enhances our immunoprecipitation experiments.
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