Recombinant Human Lymphotoxin Alpha
Cat.No. : | LTA-260H |
Product Overview : | Recombinant HumanLymphotoxin Alpha is a protein produced ininsect cellscontaining 172 amino acid residues and has an approximate molecular weight of 19.3 kDa based on SDS-PAGE gel and Mass Spectrometry due to glycosylation. |
- Specification
- Gene Information
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Cat. No. : | LTA-260H |
Description : | Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokineproduced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. |
Source : | Insect cells. |
Purity : | > 95% by SDS-PAGE and HPLC analysis. |
Endotoxin Level : | < 0.1 ng per μg of TNF-beta. |
Stabilizer : | None. |
Formulation : | Lyophilized. |
Biologically Activity : | The ED50was determined by the cytolysis of murine L929 cells in the presence of actinomycin D is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg. |
Reconstitution : | The human TNF-beta should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C. |
Stability : | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human TNF-beta should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles. |
Gene Name : | LTA lymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ] |
Synonyms : | LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factorbeta; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; OTTHUMP00000029184; OTTHUMP00000037612; OTTHUMP00000037613 |
Gene ID : | 4049 |
mRNA Refseq : | NM_000595 |
Protein Refseq : | NP_000586 |
MIM : | 153440 |
UniProt ID : | P01374 |
Chromosome Location : | 6p21.3 |
Pathway : | Antigen processing and presentation; Cytokine-cytokine receptor interaction; Type I diabetes mellitus |
Function : | cytokine activity; tumor necrosis factor receptor binding |
Products Types
◆ Native Protein | ||
LTA-15B | Native Bacillus subtilis LTA Protein | +Inquiry |
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LTA-18S | Native S. aureus LTA Protein | +Inquiry |
◆ Lysates | ||
LTA-9167HCL | Recombinant Human LTA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionLTA protein is being investigated for its potential use in cancer therapy, autoimmune diseases, and infectious diseases.
Clinical trials may have been initiated to investigate the therapeutic potential of LTA protein since my last update. It's advisable to check the latest information.
Potential side effects may include immune-related adverse events, such as inflammation and cytokine release syndrome.
LTA protein has been studied for its potential to modulate autoimmune responses, but more research is needed.
LTA protein has shown potential in cancer immunotherapy by targeting and destroying cancer cells.
Customer Reviews (3)
Write a reviewIts purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.
Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.
The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.
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