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Recombinant Human Lymphotoxin Alpha

Cat.No. : LTA-260H
Product Overview : Recombinant HumanLymphotoxin Alpha is a protein produced ininsect cellscontaining 172 amino acid residues and has an approximate molecular weight of 19.3 kDa based on SDS-PAGE gel and Mass Spectrometry due to glycosylation.
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Cat. No. : LTA-260H
Description : Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokineproduced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.
Source : Insect cells.
Purity : > 95% by SDS-PAGE and HPLC analysis.
Endotoxin Level : < 0.1 ng per μg of TNF-beta.
Stabilizer : None.
Formulation : Lyophilized.
Biologically Activity : The ED50was determined by the cytolysis of murine L929 cells in the presence of actinomycin D is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg.
Reconstitution : The human TNF-beta should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Stability : The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted human TNF-beta should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles.
Gene Name : LTA lymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ]
Synonyms : LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factorbeta; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; OTTHUMP00000029184; OTTHUMP00000037612; OTTHUMP00000037613
Gene ID : 4049
mRNA Refseq : NM_000595
Protein Refseq : NP_000586
MIM : 153440
UniProt ID : P01374
Chromosome Location : 6p21.3
Pathway : Antigen processing and presentation; Cytokine-cytokine receptor interaction; Type I diabetes mellitus
Function : cytokine activity; tumor necrosis factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are some potential therapeutic applications of LTA protein? 02/21/2023

LTA protein is being investigated for its potential use in cancer therapy, autoimmune diseases, and infectious diseases.

Are there any clinical trials involving LTA protein? 06/22/2022

Clinical trials may have been initiated to investigate the therapeutic potential of LTA protein since my last update. It's advisable to check the latest information.

What are some potential side effects or adverse reactions associated with LTA protein therapy? 03/19/2021

Potential side effects may include immune-related adverse events, such as inflammation and cytokine release syndrome.

Can LTA protein be used to treat autoimmune diseases? 08/11/2018

LTA protein has been studied for its potential to modulate autoimmune responses, but more research is needed.

Can LTA protein be used in cancer treatment? 04/05/2017

LTA protein has shown potential in cancer immunotherapy by targeting and destroying cancer cells.

Customer Reviews (3)

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Reviews
04/14/2020

    Its purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.

    01/03/2020

      Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.

      08/24/2017

        The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.

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