Recombinant Human ABL1, SH3 Domain, GST-tagged

Cat. No.

ABL1-162H

Description

N-terminal GST tagged Abl SH3 domain. Abl SH3 domain is the SH3 domain of Abl tyrosine kinase. SH3 domains are known to bind proline rich peptides. The Abl SH3 domain has been expressed as a fusion protein with GST allowing expression in E. coli and purification by affinity chromatography. The native GST-Abl-SH3 is the ideal tool for in vitro/in vivo investigations of the behaviour of cellular prions. It may be used for protein-protein interaction studies as well as for in vitro/in vivo conversion studies. The GST-Tag facilitates the protein‘s application in typical GST pull-down assays.

Source

E. coli.

Form

Lyophilized.

Purity

≥90% by SDS-PAGE.

Usage

For in vitro use only.

Storage

Quality guaranteed for 12 months store at -20^oC. Avoid freeze / thaw cycles.

Gene Information

Gene Name

ABL1 c-abl oncogene 1, receptor tyrosine kinase [ Homo sapiens ]

Synonyms

ABL1; c-abl oncogene 1, receptor tyrosine kinase; ABL; JTK7; p150; c-ABL; v-abl; bcr/abl; bcr/c-abl oncogene protein; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1; EC 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; OTTHUMP00000022375; OTTHUMP00000022376

GeneID

25

mRNA Refseq

NM_005157

Protein Refseq

NP_005148

MIM

189980

UniProt ID

P00519

Chromosome Location

9q34.1

Pathway

Axon guidance; Cell cycle; Chronic myeloid leukemia; ErbB signaling pathway; Neurotrophin signaling pathway; Pathogenic Escherichia coli infection; Pathways in cancer

Function

ATP binding; DNA binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein C-terminus binding; transferase activity