Active Recombinant Human B-cell CLL/lymphoma 10
Cat.No. : | BCL10-1016H |
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Cat. No. : | BCL10-1016H |
Description : | Bcl-10 is an intracellular signaling protein identified from the t (p22;q32) breakpoint in MALT lymphomas. The human Bcl-10 gene encodes a protein of 233 amino acids containing an N-terminal Caspase Recruitment Domain (CARD) that mediates self-oligomerization and the Cterminal region of Bcl-10. Bcl-10 is expressed ubiquitously with highexpression levels in lymphoid tissues and in the developing central nerve system. Mutations have been found in cases of follicular lymphoma and diffuse large B cell lymphoma. Bcl-10 is a positive regulator of antigenreceptor induced NF-B activation and Bcl-10-initiated activation of NF-B can be inhibited by cotransfection of dominant-negative mutants of TRAF2, NIK, IKKa or IkBa. The wild type human Bcl-10 protein was expressed in baculovirus system and purified by an affinity column in combination with FPLC chromatography. Purified protein is greater than 95% homogeneous and contains no detectable proteases, DNase, and RNase activity. |
Source : | Sf9 insect cells. |
Form : | Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol. |
Purity : | > 95% by SDS-PAGE. |
Activity : | 100 ng are required for a protein-protein interaction assay. |
Application : | Recombinant Bcl-10 protein can be used for 1) protein-protein interaction assay 2) for in vitro transcription assay 3) for cell growth assay. |
Usage : | For in vitro use only. |
Storage : | Quality guaranteed for 12 months store at -80°C Avoid freeze / thaw cycles |
Gene Name : | BCL10 B-cell CLL/lymphoma 10 [ Homo sapiens ] |
Synonyms : | BCL10; B-cell CLL/lymphoma 10; CLAP; mE10; CIPER; c-E10; CARMEN; OTTHUMP00000011647; OTTHUMP00000036080; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-like apoptotic protein;Bcl-10; B-cell CLL/lymphoma 10; hCLAP; Cellular-E10; mE10; Mammalian CARD-containing adapter molecule E10; cCARMEN; Cellular homolog of vCARMEN; Cellular homolog of vCARMEN |
Gene ID : | 8915 |
mRNA Refseq : | NM_003921 |
Protein Refseq : | NP_003912 |
MIM : | 603517 |
UniProt ID : | O95999 |
Chromosome Location : | 1p22 |
Pathway : | B cell receptor signaling pathway; T cell receptor signaling pathway |
Function : | NF-kappaB binding; kinase activator activity; protein C-terminus binding; protein kinase B binding; protein self-association; transcription coactivator activity; ubiquitin binding; ubiquitin protein ligase binding |
Products Types
◆ Recombinant Protein | ||
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BCL10-16H | Recombinant Human BCL10 Protein, His-tagged | +Inquiry |
BCL10-614R | Recombinant Rat BCL10 Protein, His (Fc)-Avi-tagged | +Inquiry |
BCL10-521R | Recombinant Rhesus monkey BCL10 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
BCL10-8490HCL | Recombinant Human BCL10 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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