Chloride intracellular channel 4

Cat. No.

CBCRY20

Background

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).

Molecular description

Protein Classification

Transport protein

Structure Weight

89641.50 Da

Polymer

1

Molecule

Chloride intracellular channel protein 4

Chain Length

261 amino acids

Crystal Description

PDB ID

2D2Z

MMDB ID

39169

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.8?

Gene information

Gene Name

CLIC4

Synonyms

CLIC4L; DKFZp566G223; FLJ38640; H1; MTCLIC; huH1; p64H1; OTTHUMP00000003380; chloride intracellular channel 4 like; Intracellular chloride ion channel protein p64H1

UniProt ID

Q9Y696

GeneID

25932

Chromosome  Location

1p36.11

Function

chloride ion binding; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity.

Reference

Li, Y.F.,  Li, D.F.,  Zeng, Z.H.,  Wang, D.C. (2006) Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals Biochem.Biophys.Res.Commun. 343: 1272-1278