Recombinant Mouse Adipoq (Trimer), Flag-tagged
Cat.No. : | Adipoq-118M |
Product Overview : | Recombinant Mouse Adipoq (trimer) was produced inHEK293. The cystenine 39 was replaced with alanine (C39A)9. mAd-C39A can only form trimer, but not hexamer or HMW form. |
- Specification
- Gene Information
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Cat. No. : | Adipoq-118M |
Description : | Adiponectin, also known as apM1, Acrp30, GBP28 and adipoQ, is a circulating hormone predominantly produced from adipose tissue. Many pharmacological studies demonstrated that this protein possesses potent anti-diabetic, anti-atherogenic and anti-inflammatory functions. Supplement of adiponectin protein can decrease blood glucose, improve insulin sensitivity, alleviate fatty liver and prevent atherosclerosis. The protein is post-translationally modified by hydroxylation and glycosylation, and forms three different oligomeric complexes in the circulation. Many clinical studies demonstrated that plasma adiponectin is an useful biomarker for metabolic syndrome, nonalcoholic steatohepatitis and certain type of cancers. Decreased circulating levels of plasma adiponectin (hypoadiponectinaemia) are associated with increased body mass index (BMI), decreased insulin sensitivity, less favourable plasma lipid profiles, increased levels of inflammatory markers and increased risk for the development of type 2 diabetes, hypertension, and coronary heart diseases. |
Source : | HEK293. |
Amino Acid Sequence : | EDDVTTTEEL APALVPPPKG TAAGWMAGIP GHPGHNGTPG RDGRDGTPGE KGEKGDAGLL GPKGETGDVG MTGAEGPRGF PGTPGRKGEP GEAAYMYRSA FSVGLETRVT VPNVPIRFTK IFYNQQNHYD GSTGKFYCNI PGLYYFSYHI TVYMKDVKVS LFKKDKAVLF TYDQYQEKNV DQASGSVLLH LEVGDQVWLQ VYGDGDHNGL YADNVNDSTF TGFLLYHDTN DYKDDDDK |
Form : | Filtered (0.22 μm) and lyophilized in 1 mg/mL in PBS. |
Purity : | >98%. |
Applications : | Binding assay, ELISA, Ex vivo and in vivo activity analysis, In vitro, Western blotting. |
Quality Control Test : | BCA to determine quantity of the protein. SDS PAGE to determine purity of the protein. |
Reconstitution : | Add deionized water to prepare a working stock solution of approximately 1 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
Storage : | Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
Gene Name : | Adipoq adiponectin, C1Q and collagen domain containing [ Mus musculus ] |
Synonyms : | Adipoq; adiponectin, C1Q and collagen domain containing; APN; Acdc; apM1; 30kDa; GBP28; adipo; Acrp30; adiponectin |
Gene ID : | 11450 |
mRNA Refseq : | NM_009605 |
Protein Refseq : | NP_033735 |
UniProt ID : | Q60994 |
Chromosome Location : | 16 16.0 cM |
Pathway : | Adipocytokine signaling pathway; PPAR signaling pathway; Type II diabetes mellitus |
Function : | hormone activity; protein binding; receptor binding |
Products Types
◆ Recombinant Protein | ||
ADIPOQ-06H | Active Recombinant Human ADIPOQ Protein | +Inquiry |
ADIPOQ-1061H | Recombinant Human Adiponectin Protein | +Inquiry |
ADIPOQ-1376H | Recombinant Human ADIPOQ Protein, MYC/DDK-tagged | +Inquiry |
ADIPOQ-087H | Recombinant Human ADIPOQ Protein, Fc-tagged | +Inquiry |
ADIPOQ-01H | Active Recombinant Human ADIPOQ Protein | +Inquiry |
◆ Native Protein | ||
ADIPOQ-215H | Native Human Adiponectin | +Inquiry |
◆ Lysates | ||
ADIPOQ-2209MCL | Recombinant Mouse ADIPOQ cell lysate | +Inquiry |
ADIPOQ-1526HCL | Recombinant Human ADIPOQ cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (12)
Ask a questionThere is limited research on the use of ADIPOQ proteins in cancer treatment. However, some studies have suggested that ADIPOQ proteins may have a protective effect against certain types of cancers, including breast, colon, and prostate cancer.
Various conditions and diseases can affect ADIPOQ protein levels, including type 2 diabetes, obesity, metabolic syndrome, polycystic ovary syndrome, and certain cancers.
Yes, ADIPOQ levels can be modulated through lifestyle changes. Regular exercise and weight loss can increase ADIPOQ levels in the blood, while a diet high in saturated fats and sugar can decrease ADIPOQ levels.
Yes, ADIPOQ proteins have been shown to have a protective effect on cardiovascular health. High levels of ADIPOQ proteins are associated with lower risk of cardiovascular disease, while low levels of ADIPOQ proteins are associated with increased risk.
Lifestyle changes such as diet and exercise can significantly affect ADIPOQ protein levels. Eating a healthy diet and maintaining a healthy weight can increase circulating levels of ADIPOQ proteins, while sedentary lifestyle and obesity can decrease ADIPOQ protein levels.
Low levels of ADIPOQ proteins in the circulation have been associated with obesity and an increased risk of metabolic disorders such as insulin resistance and type 2 diabetes. High levels of ADIPOQ proteins, on the other hand, have been associated with better insulin sensitivity and a lower risk of metabolic disorders.
Some medications, such as thiazolidinediones (TZDs), commonly used to treat type 2 diabetes, can increase ADIPOQ levels and improve insulin sensitivity. However, other medications, such as glucocorticoids, used to treat inflammatory conditions, can reduce ADIPOQ levels and worsen insulin resistance.
ADIPOQ protein levels can be measured in the circulation using a blood test or through adipose tissue biopsies. The blood test is a more commonly used diagnostic tool to evaluate ADIPOQ protein levels due to its non-invasive nature.
Yes, measuring circulating levels of ADIPOQ proteins can be used as a biomarker for metabolic disorders such as insulin resistance and type 2 diabetes. Low levels of ADIPOQ proteins are associated with an increased risk of these disorders.
Currently, there are no medications that target ADIPOQ proteins directly. However, drugs that improve insulin sensitivity and metabolic function, such as thiazolidinediones (TZDs) and metformin, have been shown to increase circulating levels of ADIPOQ proteins.
As research continues to explore the role of ADIPOQ proteins in various physiological processes, they may have potential future applications for the prevention and treatment of metabolic disorders, cardiovascular disease, infertility, and certain types of cancer. Additionally, ADIPOQ proteins may serve as a biomarker for disease and treatment response.
Customer Reviews (5)
Write a reviewthe quality of the ADIPOQ protein used in experiments is of utmost importance and can significantly impact the accuracy and reliability of the results obtained.
The packaging and shipping of the protein were both efficient and effective, ensuring that the product arrived in good condition and ready to use.
The protein's stability and shelf-life have exceeded my expectations, allowing me to use it for multiple experiments without worrying about degradation or loss of potency.
In this regard, using a protein of very high quality that meets your experimental needs is essential.
It will ensure that your results are both valid and reproducible, providing you with valuable insights into the expression and function of ADIPOQ.
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