Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse Fatty Acid Binding Protein 4, Adipocyte, His-tagged

Cat.No. : Fabp4-1004M
Product Overview : Recombinant Mouse Fabp4 was produced inE.Colifused with a his tag.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : Fabp4-1004M
Description : Fatty-acid binding protein 4(FABP4), also termed adipocyte fatty-acid binding protein (A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP-4 plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. Studies in human found FABP-4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop metabolic syndrome and type 2 diabetes. Additionally, serum FABP-4 levels were associated with carotid atherosclerosis and coronary artery disease.
Source : E.Coli.
Amino Acid Sequence : MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDLV TIRSESTFKN TEISFKLGVE FDEITADDRK VKSIITLDGG ALVQVQKWDG KSTTIKRKRD GDKLVVECVM KGVTSTRVYE RA
Form : Filtered (0.22 μm) and lyophilized in 1 mg/mL in PBS.
Purity : >95%.
Applications : ELISA, Western blotting, Immunoprecipitation
Reconstitution : Add deionized water to prepare a working stock solution of approximately 1 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Storage : Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing /thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Gene Name : Fabp4 fatty acid binding protein 4, adipocyte [ Mus musculus ]
Synonyms : Fabp4; fatty acid binding protein 4, adipocyte; Ap2; Lbpl; 422/aP2; ALBP/Ap2; adipocyte protein aP2; lipid binding protein-like
Gene ID : 11770
mRNA Refseq : NM_024406
Protein Refseq : NP_077717
UniProt ID : P04117
Chromosome Location : 313.9 cM
Pathway : PPAR signaling pathway
Function : Binding; lipid binding; transcription repressor activity; transporter activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is FABP4 involved in the development and progression of metabolic diseases? 05/31/2023

FABP4 is implicated in the development and progression of metabolic diseases due to its influence on lipid metabolism and inflammation. Elevated FABP4 expression is observed in adipose tissue and macrophages in obese individuals. FABP4 promotes lipid accumulation, insulin resistance, and the production of pro-inflammatory cytokines, leading to adipose tissue dysfunction and systemic metabolic abnormalities. Inhibition or genetic depletion of FABP4 has been shown to improve metabolic parameters in animal models, highlighting its potential as a therapeutic target for metabolic diseases.

an FABP4 be used as a biomarker for metabolic disorders? 11/10/2021

FABP4 has been investigated as a potential biomarker for metabolic disorders, including obesity and type 2 diabetes. Studies have shown that circulating levels of FABP4 are elevated in individuals with these conditions. Increased FABP4 levels have also been associated with insulin resistance, dyslipidemia, and cardiovascular risk factors. However, further research is needed to validate FABP4 as a reliable biomarker and to determine its clinical utility in the diagnosis, prognosis, and monitoring of metabolic diseases.

How does FABP4 interact with other proteins and signaling pathways? 05/05/2021

FABP4 interacts with various proteins and signaling pathways to regulate lipid metabolism and inflammation. For instance, FABP4 interacts with PPARγ, a key transcription factor involved in adipogenesis and lipid metabolism. This interaction influences the expression of genes involved in lipid uptake and storage. FABP4 also interacts with inflammatory signaling pathways, such as NF-κB and JNK, modulating the production of pro-inflammatory cytokines. Understanding the molecular interactions of FABP4 can provide insights into its functional roles and potential targets for therapeutic intervention.

What is the role of genetic variants in FABP4 in metabolic disorders? 12/20/2019

Genetic variants in the FABP4 gene have been associated with metabolic disorders. Single nucleotide polymorphisms (SNPs) in the FABP4 gene have been linked to obesity, insulin resistance, and dyslipidemia. These genetic variants may alter FABP4 expression, protein structure, or function, leading to dysregulated lipid metabolism and increased susceptibility to metabolic diseases. Further investigation is needed to elucidate the functional consequences of these genetic variants and their potential as predictive markers for metabolic disorders.

What are the potential therapeutic strategies targeting FABP4? 02/15/2019

Various therapeutic strategies targeting FABP4 have been explored. Small molecule inhibitors of FABP4 have shown promising results in preclinical studies, attenuating lipid accumulation, improving insulin sensitivity, and reducing inflammation. Additionally, gene silencing approaches, such as RNA interference, have been investigated to suppress FABP4 expression. Furthermore, modulation of FABP4 activity through natural compounds and lifestyle interventions, such as exercise and dietary modifications, may also hold therapeutic potential. However, more research is required to evaluate the safety and efficacy of these strategies in human subjects.

What is the biological function of FABP4 in cellular processes and metabolism? 06/13/2017

FABP4, also known as fatty acid-binding protein 4, plays a crucial role in lipid metabolism and cellular processes. It functions as an intracellular transporter for fatty acids, facilitating their uptake, storage, and utilization. Additionally, FABP4 modulates inflammation, insulin sensitivity, and adipocyte differentiation. Its expression is regulated by various factors such as PPARγ and C/EBPα. FABP4 dysregulation has been associated with metabolic disorders, such as obesity and type 2 diabetes, making it an important target for therapeutic interventions.

How does FABP4 contribute to the pathogenesis of cardiovascular diseases? 01/14/2016

FABP4 has been implicated in the pathogenesis of cardiovascular diseases due to its involvement in lipid metabolism, inflammation, and atherosclerosis. Elevated FABP4 levels have been observed in individuals with coronary artery disease, and FABP4 has been shown to promote foam cell formation, a key step in atherosclerotic plaque development. FABP4 also influences vascular endothelial function and thrombosis. Inhibition of FABP4 has demonstrated beneficial effects on atherosclerosis progression and cardiovascular outcomes in experimental models. Further research is needed to fully understand the mechanisms underlying the contribution of FABP4 to cardiovascular diseases.

Customer Reviews (3)

Write a review
Reviews
06/05/2021

    Unveiling a realm beyond the reaches of research, this wondrous reagent stands as the sacred partner.

    07/30/2020

      Experimentation surges forward with unrivaled celerity, guided by the efficiency of this remarkable reagent.

      10/28/2017

        The price of the reagent is relatively low, making it highly cost-effective.

        Ask a Question for All Fabp4 Products

        Required fields are marked with *

        My Review for All Fabp4 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends