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Recombinant Human Neuregulin 4, His-tagged

Cat.No. : NRG4-18H
Product Overview : Recombinant Human neuregulin 4 encoding the human sNRG4 was recombined with Hexa-histidine tag at the N-Terminus. That was expressed inE.Coli, and purified by Ni-NTA column. MW=6.7 KD.
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Cat. No. : NRG4-18H
Description : sNRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors sNRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Source : E. Coli.
Purity : >95% in SDSgel.
Formulation : Lyophilized 100 μg human NRG4 in 50 μl of TBS ( 20 mM Tris, 50mM NaCl, pH8.0 ). Carry free.
Reconstitution : Add 500μl deionized water or TBS to the vial to prepare a working stock solution at 200 μg/mL. Allow to set at least 30 minutes at 4℃, mix well.
Application : Cell biology, ELISA.
Storage : Store lyophilized protein at -20℃ to-70℃. Lyophilized protein is stable for up to 6 months from date of receipt at - 20℃ to -70℃. Upon reconstitution, this protein can be stored at -20℃ for up to a few weeks or at -70℃ in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freeze / thaw cycles.
Gene Name : NRG4 neuregulin 4 [ Homo sapiens ]
Synonyms : NRG4;neuregulin 4; HRG4; DKFZp779N0541; DKFZp779N1944; Pro-neuregulin-4, membrane-bound isoform; Pro-NRG4; Neuregulin-4; NRG-4; OTTHUMP00000183575; heregulin 4
Gene ID : 145957
mRNA Refseq : NM_138573
Protein Refseq : NP_612640
MIM : 610894
UniProt ID : Q8WWG1
Chromosome Location : 15q23
Pathway : ErbB signaling pathway
Function : growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can the function of NRG4 be studied by overexpression techniques? 12/08/2022

The function of NRG4 can be studied through overexpression techniques, such as the use of gene transfection or viral transduction. These techniques can increase the expression level of NRG4 to observe its effects on cell growth, differentiation, and survival, among other things.

What is the role of NRG4 in tissues such as the heart, nerves, and muscles? 12/03/2021

It has a variety of roles in tissues such as the heart, nerves, and muscles, including promoting cell growth, differentiation, and survival, as well as regulating synaptic plasticity and nerve signaling.

What is the physiological function of NRG4 in the heart? 11/09/2021

In the heart, NRG4 can promote cardiomyocyte growth and survival, maintain cardiomyocyte electrophysiological properties, and regulate cardiac rhythms.

How can I measure the expression level of NRG4 in tissues and cells? 07/07/2021

Immunohistochemistry, western blotting, and real-time PCR can be used to detect NRG4 expression levels in tissues and cells. These techniques can be used to assess NRG4 expression in different tissues and cells.

How does NRG4 interact with target cell surface receptors? 10/13/2020

NRG4 activates receptor phosphorylation by interacting with its receptors ErbB3 and ErbB4, which in turn triggers intracellular signaling pathways.

Is there a regulatory role for the interaction between NRG4 and other proteins? 01/26/2020

The interaction between NRG4 and other proteins is regulated by a variety of mechanisms, including through the formation of complexes, through interaction motifs at the interface of protein interactions, and by regulating conformational changes of proteins. These interactions can be modulated to achieve specific physiological functions.

Customer Reviews (3)

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Reviews
09/08/2022

    NRG4 had the intended biological effect in the experiment.

    08/04/2021

      The experimental results using NRG4 are accurate and reliable, and the data are scientific.

      06/17/2021

        NRG4's products have been widely recognized and applied in the research of related fields.

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