Dynein Light Chain Dnlc2a
| Cat.No. : | CBCRY31 |
- Specification
- Gene Information
- Related Products
| Cat. No. : | CBCRY31 |
| Background : | The human light chain of the motor protein dynein, Dnlc2A, is also a novel TGF-beta-signaling component, which is altered with high frequency in epithelial ovarian cancer. It is an important mediator of dynein and the development of cancer, owing to its ability to bind to the dynein intermediate light chain (DIC) IC74 and to regulate TGF-beta-dependent transcriptional events. |
| Protein Classification : | Transport Protein |
| Structure Weight : | 24324.71 Da |
| Polymer : | 1 |
| Molecule : | Dynein light chain 2A, cytoplasmic |
| Chain Length : | 106 amino acids |
| PDB ID : | 2HZ5 |
| MMDB ID : | 53434 |
| Source : | E.coli |
| Method : | X-Ray Diffraction |
| Resolution : | 2.10Å |
| Ligand Chemical Component : | Cesium ion |
| Reference : | Liu, J.-F., Wang, Z.-X., Wang, X.-Q., Tang, Q., An, X.-M., Gui, L.-L., Liang, D.-C. (2006) Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74 Biochem.Biophys.Res.Commun. 349: 1125-1129 |
| Gene Name : | DYNLRB1 |
| Synonyms : | BITH; BLP; DNCL2A; DNLC2A; ROBLD1; OTTHUMP00000030691; ROBL/LC7-like 1; Roadblock-1; bithoraxoid-like protein; cytoplasmic dynein light chain 2A; dynein, cytoplasmic, light polypeptide 2A; dynein-associated protein HKM23; dynein-associated protein Km23; roadblock domain containing 1 |
| UniProt ID : | Q9NP97 |
| Gene ID : | 83658 |
| Chromosome Location : | 20q11.21 |
| Function : | microtubule motor activity; protein binding |
Products Types
| ◆ Recombinant Protein | ||
| CRY26 | Recombinant Human Dynein Light Chain Dnlc2a | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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