Recombinant Human V-raf-1 Murine Leukemia Viral Oncogene Homolog 1
- Specification
- Gene Information
- Related Products
| Cat. No. : |
RAF1-1122H |
| Description : |
Raf is a member of the serine/threonine proteine kinase family involved in regulation of cell growth and differentiation and is the most important effector of Ras. Full-length Raf is composed of three conserved regions responsible for interaction with Ras, for phosphorylation and for catalytic activity. RafRBD (Ras binding domain, amino acids 50-132) mediates interaction with membrane-anchored Ras necessary for activation of the kinase activity of Raf. |
| Source : |
E.coli. |
| Molecular Weight : |
9.4 kDa (amino acids 50 - 132). |
| Form : |
Liquid. Supplied in 32 mM Tris-HCl pH 7.6, 200 mM NaCl, 5 mM MgCl2 and 5 mM DTT. |
| Purity : |
≥95% by SDS-PAGE. |
| Usage : |
For in vitro use only. |
| Storage : |
Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles. |
| Gene Name : |
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 [ Homo sapiens ] |
| Synonyms : |
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1; NS5; CRAF; Raf-1; c-Raf; Oncogene RAF1; raf proto-oncogene serine/threonine protein kinase; EC 2.7.11.1; C-RAF; cRaf |
| Gene ID : |
5894 |
| mRNA Refseq : |
NM_002880 |
| Protein Refseq : |
NP_002871 |
| MIM : |
164760 |
| UniProt ID : |
P04049 |
| Chromosome Location : |
3p25 |
| Pathway : |
Acute myeloid leukemia; B cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway; VEGF signaling pathway; Vascular smooth muscle contraction |
| Function : |
ATP binding; metal ion binding; nucleotide binding; protein serine/threonine kinase activity; receptor signaling protein activity; transferase activity; zinc ion binding |
Products Types
Related Gene
RAF1
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
