Recombinant Human RAP1B, Member Of RAS Oncogene Family

• Cat.No.: RAP1B-1127H

Specification

• Cat. No.: RAP1B-1127H
• Description: Rap (Ras-proximate) proteins are GTPases that belong to the Ras superfamily of small GTP binding proteins. Rap1B is known to antagonize the mitotic and transforming activity of Ras. Rap1B can be activated by cAMP known to either stimulate or inhibit cell proliferation. The deletion of 17 C-terminal amino acids in Rap1B △C leads to the loss of the phosphorylation site Ser179 and the geranyl-geranylation site. Protein preparation is 53% GDP- and 47% GTP-loaded, measured by HPLC.MW = 19.0 kDa.
• Source: E. coli.
• Purity: > 95% by SDS-PAGE.
• Form: Liquid. Supplied in 64 mM Tris-HCl pH 7.0, 5 mM DTE, 400 mM NaCl, 10 mM MgCl2 and 0.1 mM GDP.
• Storage: Quality guaranteed for 12 months. Store at -80°C.Avoid freeze / thaw cycles.
• Usage: For in vitro use only.

Gene Information

• Gene Name: RAP1B RAP1B, member of RAS oncogene family [ Homo sapiens ]
• Synonyms: RAP1B, member of RAS oncogene family; K-REV; RAL1B; DKFZp586H0723; RAP1B; RAS-related protein RAP1B; small GTP binding protein; Ras family small GTP binding protein RAP1B; OTTHUMP00000165026; GTP-binding protein smg p21B
• Gene ID: 5908
• mRNA Refseq: NM_001010942
• Protein Refseq: NP_001010942
• MIM: 179530
• UniProt ID: P61224
• Chromosome Location: 12q14
• Pathway: Chemokine signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Long-term potentiation; MAPK signaling pathway; Neurotrophin signaling pathway; Renal cell carcinoma; Diabetes pathways; Hemostasis; Integrin cell surface interactions
• Function: GTP binding; GTPase activity; nucleotide binding; protein binding