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Recombinant Human Creatine Kinase, Brain

Cat.No. : CKB-195H
Product Overview : Recombinant Human CKBBI produced inPichia Pastorisis a glycosylated polypeptide chain having an identical amino acid sequence compared to the native enzyme, purified under non-denaturing conditions and reacts with polyclonal antibodies to BB Isoenzyme in ELISA. The CKBBI is purified by proprietary chromatographic techniques.
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  • Gene Information
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Cat. No. : CKB-195H
Description : Creatine Kinase BB is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP: guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.
Source : Pichia Pastoris.
Physical Appearance : Sterile Filtered colourless liquid formulation.
Formulation : The protein (2.2 mg/ml) contains 10mM Bis-Tris-HCl pH-6.2, 50% glycerol, 0.5mM EDTA and 0.5mM DTT.
Stability : CKBBI although stable at 15°C for 7 days, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Biological Activity : The biological activity measured by the enzymatic activity of Creatine phosphokinase procedure No.45-UV, 1IU-1 µmole creatine phosphate was 500 IU/mg at 37°C.
Gene Name : CKB creatine kinase, brain [ Homo sapiens ]
Synonyms : CKB; creatine kinase, brain; B-CK; CKBB; creatine kinase-B; EC 2.7.3.2
Gene ID : 1152
mRNA Refseq : NM_001823
Protein Refseq : NP_001814
MIM : 123280
UniProt ID : P12277
Chromosome Location : 14q32.3
Pathway : Arginine and proline metabolism; Metabolic pathways; Metabolism of amino acids
Function : ATP binding; creatine kinase activity; nucleotide binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any other clinical markers that work in conjunction with CKB in muscle disease diagnosis? 09/18/2022

Yes, alongside CKB, other markers like Troponin and myoglobin are used to diagnose and assess muscle injuries.

What are some of the potential clinical applications of CKB protein? 01/19/2022

CKB has applications in diagnosing and monitoring neurological and muscle disorders.

How is CKB protein clinically significant? 08/10/2019

CKB protein is clinically significant because it plays a crucial role in energy metabolism in tissues like the brain.

How is CKB protein used in the diagnosis of brain-related conditions? 08/26/2018

Elevated levels of CKB in cerebrospinal fluid can indicate brain injury or neurodegenerative diseases.

Can CKB protein levels be used to monitor treatment effectiveness in muscle-related conditions? 07/05/2018

Yes, CKB levels can be monitored to assess the progress of treatment in muscle disorders.

Customer Reviews (3)

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Reviews
12/21/2020

    Highly recommended for its exceptional performance in ELISA, the CKB protein is a top contender for researchers involved in protein electron microscopy structure analysis.

    08/24/2020

      Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the CKB protein in their studies, knowing that they have the necessary resources and assistance to succeed.

      07/19/2018

        Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.

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