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Recombinant Human Thrombospondin 1

Cat.No. : THBS1-185H
Product Overview : Recombinant Human Thrombospondin 1 is glycosylated with N-linked sugars and produced using baculovirus vectors ininsect cells. Recombinant Human THBS1 is Reactive with A4.1 anti-TSP mAb and its Mw is 140,000 Dalton.
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Cat. No. : THBS1-185H
Discription : Thrombospondin-1 (TSP1) is a member of the Thrombospondin family and is encoded by the gene THBS1 which is a subunit of a disulfide-linked homotrimeric protein. Thrombospondin-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Thrombospondin-1 can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. TSP1 has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. TSP1 has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. TSP1 interacts with no less than 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with various proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase. Positive and negative modulation of endothelial cell adhesion, motility, and growth are attributed to TSP1. Recently, thrombospondin-1 was found to bind to the reelin receptors, ApoER2 and VLDLR, in so doing affecting neuronal migration in the rostral migratory stream.
Source : Baculovirus Insect Cells.
Physical Appearance : Sterile Filtered clear solution.
Formulation : The sterile protein solution contains 20mM Sodium phosphate, pH 6.0 and 300mM NaCl.
Purity : Greater than 90.0% as determined by:(a) Analysis by RP-HPLC; (b) Analysis by SDS-PAGE.
Storage : Recombinant Human TSP should be stored between 2°C- 8°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : THBS1 thrombospondin 1 [ Homo sapiens ]
Synonyms : THBS1; thrombospondin 1; TSP1; THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180
Gene ID : 7057
mRNA Refseq : NM_003246
Protein Refseq : NP_003237
MIM : 188060
UniProt ID : P07996
Chromosome Location : 15q15
Pathway : Bladder cancer; ECM-receptor interaction; Focal adhesion; TGF-beta signaling pathway; p53 signaling pathway
Function : calcium ion binding; collagen V binding; eukaryotic cell surface binding; fibrinogen binding; fibroblast growth factor 2 binding; fibronectin binding; heparin binding; identical protein binding; integrin binding; laminin binding; low-density lipoprotein binding; proteoglycan binding; structural molecule activity; transforming growth factor beta binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which tissues or cell types is THBS1 predominantly expressed? 09/01/2022

THBS1 is widely expressed but is upregulated in response to injury or in certain disease states.

How is THBS1 implicated in cancer progression? 07/10/2021

It can either promote or inhibit cancer progression, depending on the context.

How does THBS1 contribute to cell-matrix interactions? 04/28/2021

It binds to extracellular matrix components, influencing cell attachment and signaling.

What role does THBS1 play in angiogenesis? 09/14/2020

THBS1 acts as an angiogenesis inhibitor, hindering new blood vessel formation.

What therapeutic strategies are being explored targeting THBS1? 03/08/2020

Therapeutic strategies include targeting THBS1 to modulate its effects in cancer and wound healing.

What is the primary function of THBS1 in cellular processes? 06/17/2018

THBS1 modulates cell adhesion, proliferation, and migration.

Are there known genetic variations in THBS1 associated with specific diseases? 02/13/2018

Genetic variations in THBS1 have been linked to cardiovascular diseases and cancer risk.

Customer Reviews (3)

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Reviews
05/14/2022

    Quality exceeded my expectations.

    09/08/2021

      Satisfied customer, will return.

      11/21/2020

        Very pure, excellent results.

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