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Recombinant Human Aurora Kinase B, His-tagged

Cat.No. : AURKB-231H
Product Overview : Recombinant humanAurora Kinase B, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 41.4 kDa (364aa).
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Cat. No. : AURKB-231H
Description : Aurora Kinase B is a member of a family of mitotic serine/threonine kinases. Aurora Kinase B associates with chromosomes during prophase prior to relocalizing to the spindle at anaphase. Aurora Kinase B regulates chromosome segregation through the control of microtubule-kinetochore attachment and cytokinesis. Expression of Aurora Kinase B during the G2/M phase transition is tightly coordinated with histone H3 phosphorylation, while overexpression in many kinds of cancers.
Source : E.coli.
Amino Acid Sequence : MGSSHHHHHH SSGLVPRGSH MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH QLRREIEIQA HLHHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSC TFDEQRTATI MEELADALMY CHGKKVIHRD IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL PPEMIEGRMH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPMGA QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA
Form : Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 0.5mM DTT, 20% glycerol, 0.1mM EDTA, 0.1mM EGTA, 0.1M NaCl, 0.1mM PMSF.
Purity : > 90% by SDS – PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Publication :
Cdt1 stabilizes kinetochore–microtubule attachments via an Aurora B kinase–dependent mechanism (2018)
Gene Name : AURKB aurora kinase B [ Homo sapiens ]
Synonyms : AURKB; aurora kinase B ; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; aurkb-sv1; aurkb-sv2; aurora-1 aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; serine/threonine kinase 12; EC 2.7.11.1; Aurora- and Ipl1-like midbody-associated protein 1; Aurora-related kinase 2; Aurora/IPL1-related kinase 2
Gene ID : 9212
mRNA Refseq : NM_004217
Protein Refseq : NP_004208
MIM : 604970
UniProt ID : Q96GD4
Chromosome Location : 17p13.1
Function : ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the interactions between AURKB protein and cell cycle regulatory proteins? 12/03/2022

AURKB protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, INCENP, Survivin, etc., to regulate the progression of cell mitosis.

What are the intracellular substrates of AURKB protein? 09/09/2022

The substrates of AURKB include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins. Phosphorylation modification of these substrates regulates chromosome segregation and cell division during mitosis.

What is the cellular localization of AURKB protein? 06/30/2021

AURKB protein is mainly located in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

What is the expression pattern of AURKB gene? 08/11/2020

The expression of the AURKB gene is regulated by cell cycle regulators and other transcription factors and is mainly expressed in the mitotic phase of cells.

How does AURKB protein activity work? 03/14/2020

The activity of AURKB protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKB protein reach its peak expression? 04/08/2019

The protein reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

Customer Reviews (3)

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Reviews
12/28/2021

    AURKB's exceptional repeatability allows for its reliable use in a range of applications, making it a top choice for researchers.

    08/31/2021

      Very pure and can be used with confidence.

      02/03/2019

        The quality is very high and very reliable.

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