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Recombinant Human Chromatin Modifying Protein 2A, His-tagged

Cat.No. : CHMP2A-1396H
Product Overview : Recombinant Human CHMP2A protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. Mw = 27.2 kDa (242aa).
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Cat. No. : CHMP2A-1396H
Description : CHMP2A, also known as chromatin modifying protein 2A, belongs to the SNF7 family and it is component of the ESCRT III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation.
Source : E.coli.
Amino Acid Sequence : MGSSHHHHHH SSGLVPRGSH MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD
Form : Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1 M NaCl 1mM DTT, and 30% glycerol.
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : CHMP2A chromatin modifying protein 2A [ Homo sapiens ]
Synonyms : CHMP2A; chromatin modifying protein 2A; BC2; BC-2; VPS2; CHMP2; VPS2A; VPS2 homolog A; putative breast adenocarcinoma marker (32kD); CHMP2a; Vps2-1; hVps2-1; Chromatin-modifying protein 2a; Putative breast adenocarcinoma marker BC-2; Vacuolar protein-sorting-associated protein 2-1; VPS2 homolog A (S. cerevisiae)
Gene ID : 27243
mRNA Refseq : NM_014453
Protein Refseq : NP_055268
MIM : 610893
UniProt ID : O43633
Chromosome Location : 19q13.43
Pathway : Endocytosis
Function : protein domain specific binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic approaches targeting CHMP2A for neurodegenerative diseases? 01/07/2023

Research into potential therapies targeting CHMP2A is ongoing, but no specific treatments have been approved yet.

How is CHMP2A protein involved in autophagy? 05/31/2022

CHMP2A is involved in the autophagic process by helping in the formation of autophagosomes and lysosome fusion, which is essential for cellular recycling.

How does CHMP2A dysfunction affect cellular homeostasis? 04/08/2022

Dysfunction in CHMP2A can disrupt cellular homeostasis by impairing the proper sorting and degradation of cellular components, leading to cellular stress.

Can CHMP2A be used as a diagnostic marker for neurodegenerative diseases? 04/04/2021

CHMP2A mutations can be detected in some cases of hereditary spastic paraplegia, but it's not commonly used as a diagnostic marker for other neurodegenerative diseases.

What are the potential implications of CHMP2A dysfunction in the immune system? 08/05/2016

CHMP2A plays a role in antigen presentation, and its dysfunction could impact the immune response.

Customer Reviews (3)

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Reviews
09/13/2019

    Such manufacturer support fosters a conducive environment for successful and impactful research outcomes.

    01/27/2019

      By considering these advantages and the supportive role of manufacturers, researchers studying CHMP2A protein can benefit from high-quality products, technical assistance, customization options, product validation, and potential collaborations.

      06/05/2018

        This information ensures that researchers have a clear understanding of the product's performance attributes, and enables them to select the most suitable protein preparation for their experiments.

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