Recombinant Human Chromatin Modifying Protein 2A, His-tagged
Cat.No. : | CHMP2A-1396H |
Product Overview : | Recombinant Human CHMP2A protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. Mw = 27.2 kDa (242aa). |
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- Gene Information
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Cat. No. : | CHMP2A-1396H |
Description : | CHMP2A, also known as chromatin modifying protein 2A, belongs to the SNF7 family and it is component of the ESCRT III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. |
Source : | E.coli. |
Amino Acid Sequence : | MGSSHHHHHH SSGLVPRGSH MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD |
Form : | Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1 M NaCl 1mM DTT, and 30% glycerol. |
Purity : | > 90% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | CHMP2A chromatin modifying protein 2A [ Homo sapiens ] |
Synonyms : | CHMP2A; chromatin modifying protein 2A; BC2; BC-2; VPS2; CHMP2; VPS2A; VPS2 homolog A; putative breast adenocarcinoma marker (32kD); CHMP2a; Vps2-1; hVps2-1; Chromatin-modifying protein 2a; Putative breast adenocarcinoma marker BC-2; Vacuolar protein-sorting-associated protein 2-1; VPS2 homolog A (S. cerevisiae) |
Gene ID : | 27243 |
mRNA Refseq : | NM_014453 |
Protein Refseq : | NP_055268 |
MIM : | 610893 |
UniProt ID : | O43633 |
Chromosome Location : | 19q13.43 |
Pathway : | Endocytosis |
Function : | protein domain specific binding |
Products Types
◆ Recombinant Protein | ||
CHMP2A-1249H | Recombinant Human CHMP2A Protein, GST-Tagged | +Inquiry |
CHMP2A-1650M | Recombinant Mouse CHMP2A Protein, His (Fc)-Avi-tagged | +Inquiry |
Chmp2a-2146M | Recombinant Mouse Chmp2a Protein, Myc/DDK-tagged | +Inquiry |
CHMP2A-675R | Recombinant Rhesus Macaque CHMP2A Protein, His (Fc)-Avi-tagged | +Inquiry |
CHMP2A-27958TH | Recombinant Human CHMP2A, His-tagged | +Inquiry |
◆ Lysates | ||
CHMP2A-7532HCL | Recombinant Human CHMP2A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionResearch into potential therapies targeting CHMP2A is ongoing, but no specific treatments have been approved yet.
CHMP2A is involved in the autophagic process by helping in the formation of autophagosomes and lysosome fusion, which is essential for cellular recycling.
Dysfunction in CHMP2A can disrupt cellular homeostasis by impairing the proper sorting and degradation of cellular components, leading to cellular stress.
CHMP2A mutations can be detected in some cases of hereditary spastic paraplegia, but it's not commonly used as a diagnostic marker for other neurodegenerative diseases.
CHMP2A plays a role in antigen presentation, and its dysfunction could impact the immune response.
Customer Reviews (3)
Write a reviewSuch manufacturer support fosters a conducive environment for successful and impactful research outcomes.
By considering these advantages and the supportive role of manufacturers, researchers studying CHMP2A protein can benefit from high-quality products, technical assistance, customization options, product validation, and potential collaborations.
This information ensures that researchers have a clear understanding of the product's performance attributes, and enables them to select the most suitable protein preparation for their experiments.
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