Recombinant Human Profilin 1
Cat.No. : | PFN1-1401H |
Product Overview : | Recombinant Human Profilin1 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 15.0 kDa (140aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | PFN1-1401H |
Description : | Profilin1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. This protein significantly enhances skin wound healing in-vitro and in-vivo that may be mediated by purinergic receptors. It is also active in endothelial cell migration and vessel sprouting. It is thought to regulate actin polymerization in response to extracellular signals. |
Source : | E.coli. |
Amino Acid Sequence : | MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY |
Form : | Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol. |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1.0 mg/ml (determined by Bradford assay). |
Endotoxin Level : | < 1.0 EU per 1 μg of protein (determined by LAL method). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | PFN1 profilin 1 [ Homo sapiens ] |
Synonyms : | PFN1; profilin 1; Profilin-1; Profilin I |
Gene ID : | 5216 |
mRNA Refseq : | NM_005022 |
Protein Refseq : | NP_005013 |
MIM : | 176610 |
UniProt ID : | P07737 |
Chromosome Location : | 17p13.2 |
Pathway : | Regulation of actin cytoskeleton |
Function : | Rho GTPase binding; actin binding; proline-rich region binding |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, PFN1 is involved in processes such as endocytosis, cytokinesis, and cell signaling, highlighting its importance in various cellular functions.
Research on targeting PFN1 in cancer therapy is ongoing, and there are clinical trials exploring potential drugs that could inhibit PFN1 activity to impede cancer cell metastasis.
PFN1 has been found to promote cancer cell migration and invasion, suggesting its role in cancer metastasis, making it a potential target for cancer therapy.
Yes, researchers are exploring the potential of developing drugs that target PFN1 to modulate its activity, especially in the context of cancer metastasis and neurodegenerative disorders.
PFN1 regulates cell motility and migration by controlling the dynamics of actin filaments, essential components of the cell's cytoskeleton involved in cell movement.
Customer Reviews (3)
Write a reviewThe manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.
Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.
One of the key advantages of using PFN1 protein in trials is its high quality.
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