Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human Profilin 1

Cat.No. : PFN1-1401H
Product Overview : Recombinant Human Profilin1 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 15.0 kDa (140aa).
  • Specification
  • Gene Information
  • Related Products
Cat. No. : PFN1-1401H
Description : Profilin1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. This protein significantly enhances skin wound healing in-vitro and in-vivo that may be mediated by purinergic receptors. It is also active in endothelial cell migration and vessel sprouting. It is thought to regulate actin polymerization in response to extracellular signals.
Source : E.coli.
Amino Acid Sequence : MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY
Form : Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
Purity : > 95% by SDS – PAGE.
Concentration : 1.0 mg/ml (determined by Bradford assay).
Endotoxin Level : < 1.0 EU per 1 μg of protein (determined by LAL method).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : PFN1 profilin 1 [ Homo sapiens ]
Synonyms : PFN1; profilin 1; Profilin-1; Profilin I
Gene ID : 5216
mRNA Refseq : NM_005022
Protein Refseq : NP_005013
MIM : 176610
UniProt ID : P07737
Chromosome Location : 17p13.2
Pathway : Regulation of actin cytoskeleton
Function : Rho GTPase binding; actin binding; proline-rich region binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is PFN1 protein involved in any other cellular processes apart from cell motility? 11/09/2021

Yes, PFN1 is involved in processes such as endocytosis, cytokinesis, and cell signaling, highlighting its importance in various cellular functions.

Are there ongoing clinical trials targeting PFN1 for cancer treatment? 09/30/2020

Research on targeting PFN1 in cancer therapy is ongoing, and there are clinical trials exploring potential drugs that could inhibit PFN1 activity to impede cancer cell metastasis.

How does PFN1 protein contribute to cancer progression? 05/30/2020

PFN1 has been found to promote cancer cell migration and invasion, suggesting its role in cancer metastasis, making it a potential target for cancer therapy.

Can PFN1 protein be targeted for drug development? 12/22/2019

Yes, researchers are exploring the potential of developing drugs that target PFN1 to modulate its activity, especially in the context of cancer metastasis and neurodegenerative disorders.

How does PFN1 protein affect cell motility and migration? 05/03/2016

PFN1 regulates cell motility and migration by controlling the dynamics of actin filaments, essential components of the cell's cytoskeleton involved in cell movement.

Customer Reviews (3)

Write a review
Reviews
08/26/2021

    The manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.

    06/22/2021

      Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.

      11/09/2020

        One of the key advantages of using PFN1 protein in trials is its high quality.

        Ask a Question for All PFN1 Products

        Required fields are marked with *

        My Review for All PFN1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends