Recombinant Human Transforming Growth Factor, beta 1

• Cat.No.: TGFB1-126H
• Product Overview: Recombinant human TGF-β1 protein was expressed in E.coli and purified by using conventional chromatography techniques. MW=12.9 kDa (113aa).

Specification

• Cat. No.: TGFB1-126H
• Description: Transforming growth factor beta 1(TGF-β1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. Many cells synthesize TGFb1 and almost all of them have specific receptors for it. It positively and negatively regulates many other growth factors. Also, TGF-β1 plays an important role in bone remodeling, controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages.
• Source: E. Coli.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
• Purity: > 95% by SDS-PAGE.
• Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method ).
• Amino Acid Sequence: MALDTNYCFS STEKNCCVRQ LYIDFRKDLG WKWIHEPKGY HANFCLGPCP YIWSLDTQYS KVLALYNQHN PGASAAPCCV PQALEPLPIV YYVGRKPKVE QLSNMIVRSC KCS.
• Storage: Can be stored at +4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20°Cor -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: TGFB1 transforming growth factor, beta 1 [ Homo sapiens ]
• Synonyms: transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGFB1; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; TGF-beta-1; transforming growth factor-beta 1; diaphyseal dysplasia 1, progressive; TGF-beta 1 protein
• Gene ID: 7040
• mRNA Refseq: NM_000660
• Protein Refseq: NP_000651
• MIM: 190180
• UniProt ID: P01137
• Chromosome Location: 19q13.1
• Pathway: Cell cycle; Chronic myeloid leukemia; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway; Influenza Infection; Signaling by TGF beta; Colorectal cancer; Hemostasis
• Function: type II transforming growth factor beta receptor binding; transcription activator activity; protein homodimerization activity; protein heterodimerization activity; protein N-terminus binding; growth factor activity