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Recombinant Human NDUFS4

Cat.No. : NDUFS4-367H
Product Overview : Recombinant Human NDUFS4 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 134 amino acids (43-175 a.a.) and having a molecular mass of 15.5 kDa. The NDUFS4 is purified by proprietary chromatographic techniques.
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Cat. No. : NDUFS4-367H
Description : NDUFS4 is a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), the primary multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I is involved in cellular ATP production, the main source of energy for numerous vital processes in living cells. NDUFS4 removes electrons from NADH and passes them by a series of diverse protein-coupled redox centers to the electron acceptor ubiquinone. NDUFS4 presents a hotspot of mutations in the genetic apparatus of oxidative phosphorylation and the correct assembly of the subunit it encodes is essential for completion of the assembly of complex I.
Source : Escherichia Coli.
Amino Acid Sequence : MAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK.
Physical Appearance : Sterile Filtered colorless solution.
Formulation : The NDUFS4 solution contains 20mM Tris pH-8 & 30% glycerol.
Purity : Greater than 90.0% as determined by SDS-PAGE.
Stability : NDUFS4 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) [ Homo sapiens ]
Synonyms : NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 4; NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; mitochondrial respiratory chain complex I (18-KD subunit); AQDQ
Gene ID : 4724
mRNA Refseq : NM_002495
Protein Refseq : NP_002486
MIM : 602694
UniProt ID : O43181
Chromosome Location : 5q11.1
Pathway : Alzheimer"s disease; Huntington"s disease; Metabolic pathways; Metabolic pathways; Parkinson"s disease; Diabetes pathways; Electron Transport Chain; Integration of energy metabolism
Function : NADH dehydrogenase (ubiquinone) activity; oxidoreductase activity, acting on NADH or NADPH

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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