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Recombinant Mouse BH3 Interacting Domain Death Agonist

Cat.No. : Bid-1382M
Product Overview : Recombinant Mouse BID produced inE.Coliis a single, non-glycosylated polypeptide chain containing 1-195 amino acids and having a molecular mass of 22 kDa.
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Cat. No. : Bid-1382M
Description : BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered colorless liquid formulation.
Formulation : The Mouse BID protein solution contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Stability : BID although stable at 15°C for 1 week, should be stored desiccated below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Gene Name : Bid BH3 interacting domain death agonist [ Mus musculus ]
Synonyms : Bid; BH3 interacting domain death agonist; AI875481; AU022477; 2700049M22Rik; OTTMUSP00000028756
Gene ID : 12122
mRNA Refseq : NM_007544
Protein Refseq : NP_031570
UniProt ID : P70444
Chromosome Location : 6 F1; 6 54.0 cM
Pathway : Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Natural killer cell mediated cytotoxicity; Pathways in cancer; p53 signaling pathway
Function : protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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In which cellular processes does the BID protein play? 06/24/2022

BID protein mainly plays a role in the process of apoptosis. It can regulate cell survival and death signaling by interacting with other members of the Bcl-2 family.

Can the expression level and activity of BID protein be determined? 11/20/2020

The expression level of BID protein can be detected by immunohistochemistry, western blotting, real-time quantitative PCR and other techniques. At the same time, the activity of BID protein can be assessed by detecting the level of phosphorylation of BID protein and the number of BID protein within cells.

How are BID proteins involved in the process of apoptosis? 11/05/2020

During apoptosis, the BID protein is activated, forming complexes with other Bcl-2 family members, releasing cytochrome c, initiating a cascade of caspase enzymes, and ultimately leading to apoptosis.

How are the interactions between BID proteins and other proteins regulated? 09/21/2020

The interaction between BID protein and other proteins is regulated by a variety of factors, including phosphorylation, methylation, acetylation and other modifications, as well as interactions with other proteins. These factors can affect the interaction between BID protein and other proteins, which in turn affects the regulatory process of apoptosis.

How can BID proteins be used as biomarkers in clinical practice? 08/29/2020

In clinical practice, the expression level of BID protein can be measured to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in some tumor diseases, measuring the expression level of BID protein can help doctors determine the type, stage, and prognosis of the disease, and guide the choice of treatment regimen.

Can the expression level of BID protein be regulated? 06/12/2020

Expression level of BID protein is regulated by a variety of factors, including gene transcription, translation, modification, and degradation. These factors can affect the expression level of BID protein, which in turn affects the survival and death signals of cells.

Customer Reviews (3)

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Reviews
12/19/2021

    Activity retention time is very long and can be maintained for a long time.

    09/13/2021

      The detection method is very sensitive and can easily detect small amounts of protein.

      04/10/2021

        Expression level and stability are good and will be repurchased.

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