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Cat. No. |
BMP2-22H |
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Product
Overview |
Recombinant
Human Bone Morphogenetic Protein-2 produced in CHO is a
homodimeric, glycosylated, Polypeptide chain containing 115
amino acids and having a calculated molecular mass of 26018
Dalton. Due to its glycosilation, BMP-2 migrates on SDS-PAGE
under non-reducing conditions at 36kDa and 18kDa under reducing
conditions. The BMP-2 CHO derived protein is purified by
proprietary chromatographic techniques. |
|
Description |
BMP2 belongs to
the transforming growth factor-beta (TGFB) superfamily. Bone
morphogenic protein induces bone formation. BMP2 is a candidate
gene for the autosomal dominant disease of fibrodysplasia (myositis)
ossificans progressiva. |
|
Source |
Chinese Hamster
Ovary Cell. |
|
Physical
Appearance |
Sterile
Filtered White lyophilized (freeze-dried) powder. |
|
Formulation |
1mcg of BMP-2
was lyophilized from a sterile solution containing 0.2% sucrose,
2.5% glycine, 0.01% tween-80, 0.01% NaCl and 3% mannitol. |
|
Biological
Activity |
The ED50 as
determined by cytolysis of ATDC-5 cell is less than 50ng/ml. |
|
Solubility |
It is
recommended to reconstitute the lyophilized Bone Morphogenetic
Protein-2 in sterile water at a concentration of 100µg/ml, which
can then be further diluted to other aqueous solutions. |
|
Purity |
Greater than
95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis
by SDS-PAGE. |
|
Stability |
Lyophilized Bone Morphogenetic
Protein-2 although stable at room temperature for 3 weeks,
should be stored desiccated below -18oC. Upon reconstitution
BMP2 should be stored at 4oC between 2-7 days and for future use
below -18oC. For long term storage it is recommended to add a
carrier protein (0.1% HSA or BSA).
Please prevent
freeze-thaw cycles. |
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Gene
Information
|
Gene Name |
BMP2 bone morphogenetic protein 2 [ Homo sapiens ] |
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Synonyms
|
BMP2A; BMP-2; Bone morphogenetic protein 2 precursor;
bone
morphogenetic protein 5; BMP-2A; OTTHUMP00000016650; BMP2 |
|
GeneID |
650 |
|
mRNA Refseq |
NM_001200 |
|
Protein Refseq |
NP_001191 |
|
MIM |
112261 |
|
UniProt ID |
P12643
|
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Chromosome
Location |
20p12 |
|
Pathway |
BMP signaling
pathway; Basal cell carcinoma; Cytokine-cytokine receptor
interaction; Hedgehog signaling pathway; TGF-beta signaling
pathway |
|
Function |
Cytokine
activity, Growth factor activity, Specific transcriptional
repressor activity |
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PDB rendering based on 3bmp.
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Download Datasheet:
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