Catalog # or name ...
Human Bone Morphogenetic Protein-2 produced in CHO is a
homodimeric, glycosylated, Polypeptide chain containing 115
amino acids and having a calculated molecular mass of 26018
Dalton. Due to its glycosilation, BMP-2 migrates on SDS-PAGE
under non-reducing conditions at 36kDa and 18kDa under reducing
conditions. The BMP-2 CHO derived protein is purified by
proprietary chromatographic techniques.
BMP2 belongs to
the transforming growth factor-beta (TGFB) superfamily. Bone
morphogenic protein induces bone formation. BMP2 is a candidate
gene for the autosomal dominant disease of fibrodysplasia (myositis)
Filtered White lyophilized (freeze-dried) powder.
1mcg of BMP-2
was lyophilized from a sterile solution containing 0.2% sucrose,
2.5% glycine, 0.01% tween-80, 0.01% NaCl and 3% mannitol.
The ED50 as
determined by cytolysis of ATDC-5 cell is less than 50ng/ml.
recommended to reconstitute the lyophilized Bone Morphogenetic
Protein-2 in sterile water at a concentration of 100µg/ml, which
can then be further diluted to other aqueous solutions.
95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis
Lyophilized Bone Morphogenetic
Protein-2 although stable at room temperature for 3 weeks,
should be stored desiccated below -18oC. Upon reconstitution
BMP2 should be stored at 4oC between 2-7 days and for future use
below -18oC. For long term storage it is recommended to add a
carrier protein (0.1% HSA or BSA).
BMP2 bone morphogenetic protein 2 [ Homo sapiens ]
BMP2A; BMP-2; Bone morphogenetic protein 2 precursor;
morphogenetic protein 5; BMP-2A; OTTHUMP00000016650; BMP2
pathway; Basal cell carcinoma; Cytokine-cytokine receptor
interaction; Hedgehog signaling pathway; TGF-beta signaling
activity, Growth factor activity, Specific transcriptional
PDB rendering based on 3bmp.
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