Recombinant Human Insulin-like Growth Factor 1 Receptor, His-tagged, Active

• Cat.No.: IGF1R-330H
• Product Overview: Recombinant human IGF1R (960-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW = 53 kDa.

Specification

• Cat. No.: IGF1R-330H
• Description: IGF1R (Insulin-like Growth Factor 1) is a transmembrane tyrosine kinase receptor that is activated by IGF-1 and by the related growth factor IGF-2. IGF1R mediates the effects of IGF-1 and plays an important role in growth and anabolic effects in adults. The IGF1R is implicated in several cancers, most notably breast cancer where it is highly overexpressed and functions as an anti-apoptotic agent by enhancing cell survival. In many instances, the anti-apoptotic properties of IGF1R overexpression allows cancerous cells to resist the cytotoxic properties of chemotheraputic drugs or radiotherapy.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 960-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ]
• Synonyms: IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172; soluble IGF1R variant 1; soluble IGF1R variant 2; EC 2.7.10.1; CD221; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
• Gene ID: 3480
• mRNA Refseq: NM_000875
• Protein Refseq: NP_000866
• MIM: 147370
• UniProt ID: P08069
• Chromosome Location: 15q26.3
• Pathway: Adherens junction; Colorectal cancer; Endocytosis; Focal adhesion; Glioma; Long-term depression; Melanoma; Pathways in cancer; Prostate cancer
• Function: ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; nucleotide binding; phosphoinositide 3-kinase binding; receptor activity; transferase activity