Recombinant Human Insulin Receptor, GST-tagged, Active
Cat.No. : | INSR-331H |
Product Overview : | Recombinant human InsR (1011-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 70 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | INSR-331H |
Description : | InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, α and β that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake. Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas β cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult β cells and the central control of nutrient homeostasis. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 1011-end. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | INSR insulin receptor [ Homo sapiens ] |
Synonyms : | INSR; insulin receptor; HHF5; CD220; EC 2.7.10.1; IR; CD220 antigen; Insulin receptor subunit alpha; Insulin receptor subunit beta |
Gene ID : | 3643 |
mRNA Refseq : | NM_000208 |
Protein Refseq : | NP_000199 |
MIM : | 147670 |
UniProt ID : | P06213 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Adherens junction; Insulin signaling pathway; Type II diabetes mellitus |
Function : | 3-phosphoinositide-dependent protein kinase binding; ATP binding; GTP binding; PTB domain binding; SH2 domain binding; insulin binding; insulin receptor activity; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor receptor binding; lipoic acid binding; manganese ion binding; metal ion binding; nucleotide binding; phosphoinositide 3-kinase binding; protein complex binding; protein phosphatase binding; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity |
Products Types
◆ Lysates | ||
INSR-474HCL | Recombinant Human INSR cell lysate | +Inquiry |
INSR-2648HCL | Recombinant Human INSR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1607 | INSR Internalization Assay Kit | +Inquiry |
Kit-1605 | U2OS INSR Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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