Recombinant Human Insulin Receptor-related Receptor, GST-tagged, Active

• Cat.No.: INSRR-334H
• Product Overview: Recombinant human IRR (945-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 65 kDa.

Specification

• Cat. No.: INSRR-334H
• Description: IRR or insulin receptor-related receptor is a tyrosine protein kinase that is required for the appearance of male gonads and thus for male sexual differentiation. The expression of IRR mRNA is restricted to a few tissue types and has been detected in neuronal tissues as well as in neuroblastomas. As a result of its occurrence in neuroblastomas, it has speculated that IRR may be involved in tumor genesis. RT-PCR and solution hybridization/RNAse protection assay have shown strong coupling of IRR mRNA in 18 tumor cell lines.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 945-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: INSRR insulin receptor-related receptor [ Homo sapiens ]
• Synonyms: INSRR; insulin receptor-related receptor; IRR; IR-related receptor; EC 2.7.10.1; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; OTTHUMP00000038715
• Gene ID: 3645
• mRNA Refseq: NM_014215
• Protein Refseq: NP_055030
• MIM: 147671
• UniProt ID: P14616
• Chromosome Location: 1q21-q23
• Pathway: Prostate cancer; Regulation of actin cytoskeleton
• Function: ATP binding; manganese ion binding; metal ion binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity