Recombinant Human IL2-inducible T-cell Kinase, GST-tagged, Active
Cat.No. : | ITK-335H |
Product Overview : | Recombinant human ITK (352-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 53 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | ITK-335H |
Description : | ITK is a member of the TEC family of non-receptor tyrosine kinases. ITK is expressed in T-cells and is important for T-cell development and activation through the antigen receptor. ITK require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation and shares major substrates with both Lck and Zap-70. ITK knockout mice show multiple effects on T cell development, cytokine production and T-helper cell differentiation. T cells that lack or express mutant versions of ITK show impaired TCR-induced actin polymerization, cell polarization and regulation of the signaling events involved in cytoskeletal reorganization. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 352-end. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | ITK IL2-inducible T-cell kinase [ Homo sapiens ] |
Synonyms : | ITK; IL2-inducible T-cell kinase; EMT; LYK; PSCTK2; MGC126257; MGC126258; tyrosine-protein kinase LYK; homolog of mouse T-cell itk/tsk; tyrosine-protein kinase ITK/TSK; EC 2.7.10.2; Kinase EMT |
Gene ID : | 3702 |
mRNA Refseq : | NM_005546 |
Protein Refseq : | NP_005537 |
MIM : | 186973 |
UniProt ID : | Q08881 |
Chromosome Location : | 5q31-q32 |
Pathway : | Chemokine signaling pathway; Leukocyte transendothelial migration; T cell receptor signaling pathway |
Function : | ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
Itk-3615M | Recombinant Mouse Itk Protein, Myc/DDK-tagged | +Inquiry |
ITK-4961H | Active Recombinant Human ITK Protein | +Inquiry |
ITK-576H | Recombinant Human ITK protein(Arg352-Leu620), GST-tagged | +Inquiry |
ITK-4960H | Recombinant Human ITK Protein, GST-tagged | +Inquiry |
ITK-1223H | Recombinant Human ITK Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ITK-418MCL | Recombinant Mouse ITK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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