Recombinant Human Serine/Threonine Kinase 10, GST-tagged, Active
Cat.No. : | STK10-343H |
Product Overview : | Recombinant human LOK (1-348) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 65 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | STK10-343H |
Description : | LOK is a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. LOK can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. LOK can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. MEKK1 and LOK have opposing roles in regulating the enhancer element of the IL-2 gene during T-cell activation. While MEKK1 is responsible for the CD28 signalling pathway that activates the CD28 response element, co-expression of LOK attenuates these effects. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 1-348. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | STK10 serine/threonine kinase 10 [ Homo sapiens ] |
Synonyms : | STK10; serine/threonine kinase 10;LOK; PRO2729; lymphocyte-oriented kinase; EC 2.7.11.1 |
Gene ID : | 6793 |
mRNA Refseq : | NM_005990 |
Protein Refseq : | NP_005981 |
MIM : | 603919 |
UniProt ID : | O94804 |
Chromosome Location : | 5q35.1 |
Function : | ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
STK10-2966H | Recombinant Human STK10 Protein, MYC/DDK-tagged | +Inquiry |
Stk10-6181M | Recombinant Mouse Stk10 Protein, Myc/DDK-tagged | +Inquiry |
STK10-1120H | Recombinant Human STK10 Protein (M1-S348), Tag Free | +Inquiry |
STK10-1121H | Recombinant Human STK10 Protein (M1-S348), GST tagged | +Inquiry |
STK10-555H | Recombinant Human Serine/Threonine Kinase 10, His-tagged | +Inquiry |
◆ Lysates | ||
STK10-1711HCL | Recombinant Human STK10 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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