Recombinant Human Activin A Receptor, Type I
Cat.No. : | ACVR1-1408H |
Product Overview : | Recombinant human Activin A Receptor, Type I was expressed inInsect cells. MW=26 kDa. |
- Specification
- Gene Information
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Cat. No. : | ACVR1-1408H |
Description : | Human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues, belonging to the TGF-β family. It exhibits a wide range of biological activity including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. |
Source : | Insect cells. |
Specific Activity : | ≥5×10⁵ U/mg. |
Product Format : | Sterile filtered, lyophilized. |
Stabilizer : | None. |
Purity : | >95% (SDS-PAGE, HPLC). |
Endotoxin Level : | <0.1 ng/μg (1 EU/μg). |
Buffer : | Citric acid (10 mM, pH 3.0). |
Biological Activity : | The ED₅₀ of ≤2 ng/mL was determined by its ability to inhibit the proliferation of mouse MPC-11 cells. It corresponds to a specific activity of ≥5×10⁵ U/mg. |
Reconstitution : | We recommend a quick spin followed by reconstitution in deionized sterile-filtered water to a concentration of 50μg/mL. This solution can be stored at 4°C for 1 month or at –20°C for future use. It is recommended that further dilutions be made in PBS containing 2 mg/mL albumin and stored at –20°C. |
Storage : | The lyophilized protein is stable for a few weeks at room temperature, but best stored at –20°C for at least two years. Reconstituted Human Activin A should be stored in working aliquots at –20°C. Avoid repeated freeze-thaw cycles. |
Gene Name : | ACVR1 activin A receptor, type I [ Homo sapiens ] |
Synonyms : | ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; OTTHUMP00000204604; OTT HUMP000002 04626; hydroxyalkyl-protein kinase; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; EC 2.7.11.30 |
Gene ID : | 90 |
mRNA Refseq : | NM_001105 |
Protein Refseq : | NP_001096 |
MIM : | 102576 |
UniProt ID : | Q04771 |
Chromosome Location : | 2q23-q24 |
Pathway : | Cytokine-cytokine receptor interaction; TGF-beta signaling pathway |
Function : | ATP binding; SMAD binding; activin binding; activin receptor activity, type I; follistatin binding; gnesium ion binding; manganese ion binding; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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