Recombinant Bovine Insulin-Like Growth Factor Binding Protein 2, 36kDa

• Cat.No.: IGFBP2-1414B
• Product Overview: Recombinant bovine IGFBP-2 produced inCHO cellsis a 284 amino acid protein. MW = 30.776 kDa.

Specification

• Cat. No.: IGFBP2-1414B
• Description: Bovine Insulin-like Growth Factor Binding Protein-2 (bIGFBP-2) is one of the six “classical” IGF binding proteins that play an important role in stabilizing and regulating the activity of IGFs in vivo. bIGFBP-2 binds both human and bovine IGF-I and IGF-II and modifies their biological activity and bioavailability. The Animal/Media Grade product contains mature bovine IGFBP-2 of correct Molecular Weight as the major species. As a result of alternative processing by the CHO cells used for the bIGFBP-2 production, three other minor bIGFBP-2 isoforms are also present: 1) One with a three amino acid C-terminal deletion, denoted Des(1-3) bIGFBP-2. 2) One with a single amino acid N-terminal extension, denoted A-bIGFBP-2. 3) One with a four amino acid N-terminal extension, denoted GARA-bIGFBP-2.
• Source: CHO cells.
• Purity: >95% by HPLC and Mass Spectrometry.
• Biological Activity: IGF-I Binding Assay : ED50 < 10 nM.
• State And Appearance: Lyophilized white powder dried from 0.1% TFA / 30% acetonitrile and stored under dry nitrogen at a slight vacuum (-25 kPa).
• Storage/Stability: At least 2 years at 2 - 4°C (lyophilized).
• Publication:
  Ruminal epithelial insulin-like growth factor-binding proteins 2, 3, and 6 are associated with epithelial cell proliferation (2019)

Gene Information

• Gene Name: IGFBP2 insulin-like growth factor binding protein 2, 36kDa [ Bos taurus ]
• Synonyms: insulin-like growth factor binding protein 2, 36kDa; IGFBP2
• Gene ID: 282260
• mRNA Refseq: NM_174555
• Protein Refseq: NP_776980
• UniProt ID: P13384
• Chromosome Location: 2
• Function: insulin-like growth factor I binding; insulin-like growth factor II binding