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Recombinant Human DAPK1, GST-tagged, Active

Cat.No. : DAPK1-289H
Product Overview : Recombinant human DAPK1 (1-363) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW= 71kDa.
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Cat. No. : DAPK1-289H
Description : Death-associated protein kinase 1 (DAPK1) is a positive mediator of apoptosis induced by γ-interferon. Activation of DAPK occurs via dephosphorylation of Ser-308 and subsequent association of calcium/calmodulin. DAPK is rapidly dephosphorylated in response to tumor necrosis factor or ceramide and then subsequently degraded via proteasome activity. The decline in DAPK expression is paralleled with increased caspase activity and cell apoptosis. Studies suggest that the apoptosis regulatory activities mediated by DAPK are controlled both by phosphorylation status and protein stability.
Source : Sf9 insect cellsusing baculovirus.
Sequence : 1-363.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : DAPK1 death-associated protein kinase 1 [ Homo sapiens ]
Synonyms : DAPK1; death-associated protein kinase 1; DAPK; DKFZp781I035; EC 2.7.11.1; death associated protein kinase 1
Gene ID : 1612
mRNA Refseq : NM_004938
Protein Refseq : NP_004929
MIM : 600831
UniProt ID : P53355
Chromosome Location : 9q34.1
Pathway : Bladder cancer; Pathways in cancer
Function : ATP binding; calmodulin binding; nucleotide binding ; protein serine/threonine kinase activity transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the specific role of DAPK1 in apoptosis? 05/04/2022

DAPK1 plays an important role in apoptosis, which can promote the process of apoptosis.

How can diseases be treated by regulating DAPK1 levels? 08/16/2021

There are currently no drugs that directly regulate DAPK1 levels, but some DAPK1-related diseases can be treated by modulating its activity or regulating its expression.

What is the relationship of DAPK1 to other genes or proteins? 06/23/2020

DAPK1 has a complex relationship with other genes or proteins, and can interact with other genes or proteins to participate in a variety of biochemical reactions.

How to detect and analyze mutations in DAPK1? 05/12/2020

Mutations in DAPK1 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What are the mutation types of DAPK1? 04/20/2020

The types of mutations in DAPK1 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How to study the regulatory mechanism of DAPK1? 01/09/2020

Studying the regulatory mechanism of DAPK1 requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

Customer Reviews (3)

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Reviews
12/15/2022

    DAPK1 had the intended biological effect in the experiment.

    04/11/2022

      I've used many brands, but this one is one of my favorites.

      03/17/2022

        Good stability under different temperature and humidity conditions.

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