Recombinant Human CDC-like Kinase 1, GST-tagged, Active

• Cat.No.: CLK1-284H
• Product Overview: Recombinant human CLK1 (129-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=66 kDa.

Specification

• Cat. No.: CLK1-284H
• Description: CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins, such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors.
• Source: Sf9 insect cellsusing baculovirus.
• Sequence: 129-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CLK1 CDC-like kinase 1 [ Homo sapiens ]
• Synonyms: CLK1; CDC-like kinase 1; CLK; STY; CLK/STY; CDC28/CDC2-like kinase; protein tyrosine kinase STY; dual specificity protein kinase CLK1; EC 2.7.12.1
• Gene ID: 1195
• mRNA Refseq: NM_001162407
• Protein Refseq: NP_001155879
• MIM: 601951
• UniProt ID: P49759
• Chromosome Location: 2q33
• Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity