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Recombinant Human Cyclin-Dependent Kinase 9, GST-tagged, Active

Cat.No. : CDK9-280H
Product Overview : Recombinant human full-length CDK9 and CyclinK were co-expressed by baculovirus inSf9insect cells using an N-terminal GST tag on both proteins. MW=68 kDa and CyclinK~67 kDa.
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  • Gene Information
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Cat. No. : CDK9-280H
Description : CDK9/CyclinK is a member of the cyclin-dependent protein kinase (CDK) family. CDK9 is closely related to cdc28 and cdc2 and is an important regulator of the cell cycle. CDK9 is a component of the multiprotein complex TAK/P-TEFβ. CDK9 can modulate RNA polymerase II-directed transcription by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. CDK9 also interacts with the HIV-1 Tat protein which suggested a possible involvement of this protein in AIDS.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : CDK9 cyclin-dependent kinase 9 [ Homo sapiens ]
Synonyms : CDK9; cyclin-dependent kinase 9; TAK; C-2k; CTK1; CDC2L4; PITALRE; cyclin-dependent kinase 9 (CDC2-related kinase);Cell division protein kinase 9;EC2.7.11.22;EC2.7.11.23; Cyclin-dependent kinase 9; Serine/threonine-protein kinase; Cell division cycle 2-like protein kinase 4
Gene ID : 1025
mRNA Refseq : NM_001261
Protein Refseq : NP_001252
UniProt ID : P50750
Chromosome Location : 9q34.1
MIM : 603251
Pathway : Gene Expression; HIV Infection; Transcription
Function : ATP binding; DNA binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; snRNA binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is CDK9 targeted only for cancer and antiviral therapies, or are there other applications? 12/04/2021

Besides cancer and antiviral therapies, CDK9 is being explored for its role in other diseases, including neurodegenerative disorders.

Can CDK9 inhibitors be used in combination with other cancer treatments? 05/04/2021

Yes, combination therapies involving CDK9 inhibitors and other drugs are being investigated to enhance treatment outcomes.

How does the expression of CDK9 vary in different stages of cancer progression? 07/03/2020

CDK9 expression tends to increase as cancer progresses, suggesting its potential as a biomarker for disease severity.

How does CDK9 inhibition affect normal cellular functions? 12/22/2019

CDK9 inhibitors can impact normal cell functions, leading to potential side effects such as myelosuppression.

Are there ongoing clinical trials involving CDK9 inhibitors? 07/08/2017

Yes, several clinical trials are exploring the effectiveness of CDK9 inhibitors in different cancer types.

Customer Reviews (3)

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Reviews
08/31/2020

    Its remarkable quality, versatility, and the manufacturer's commitment to customer satisfaction make it the perfect choice for researchers seeking a premier protein that will undoubtedly enhance their experimental endeavors.

    06/26/2019

      In addition to its remarkable quality and exceptional technical support, the CDK9 Protein boasts an impressive range of applications.

      09/12/2018

        The CDK9 Protein has exceeded my expectations by consistently delivering outstanding results and providing exceptional technical support.

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