Active Recombinant Human CDK4/CCND1 Protein, GST-tagged
| Cat.No. : | CDK4/CCND1-274H |
| Product Overview : | Recombinant full-length human CDK4 and CyclinD1 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins. |
- Specification
- Gene Information
- Related Products
| Description : | CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of RB protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. |
| Source : | Insect Cell |
| Species : | Human |
| Tag : | GST |
| Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
| Bio-activity : | 12nmol/min/mg |
| Molecular Mass : | ~57 kDa and CyclinD1 ~61 kDa |
| Purity : | >75% |
| Storage : | Storage at -70 centigrade |
| Concentration : | 0.1ug/ul |
| Gene Name : | CDK4 cyclin-dependent kinase 4 [ Homo sapiens ] |
| Official Symbol : | CDK4 |
| Synonyms : | CDK4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458; |
| Gene ID : | 1019 |
| mRNA Refseq : | NM_000075 |
| Protein Refseq : | NP_000066 |
| MIM : | 123829 |
| UniProt ID : | P11802 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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