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Recombinant Human Aurora Kinase C, GST-tagged, Active

Cat.No. : AURKC-248H
Product Overview : Recombinant full-length human AURORAC was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 61 kDa.
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Cat. No. : AURKC-248H
Description : Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors. Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : AURKC aurora kinase C [ Homo sapiens ]
Synonyms : aurora kinase C; AIE2; AIK3; ARK3; AurC; STK13; aurora-C; AURKC; aurora/IPL1/EG2 protein 2; aurora/IPL1-related kinase 3; serine/threonine kinase 13 (aurora/IPL1-like); EC 2.7.11.1; Aurora-C; Aurora/Ipl1-related kinase 3; Aurora/Ipl1/Eg2 protein 2
Gene ID : 6795
mRNA Refseq : NM_001015878
Protein Refseq : NP_001015878
MIM : 603495
UniProt ID : Q9UQB9
Chromosome Location : 19q13.43
Function : protein serine/threonine kinase activity; ATP binding; nucleotide binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of AURKC protein in germ cell genesis? 12/06/2022

AURKC protein plays an important role in germ cell genesis and is involved in the development, maturation and fertilization of sperm and egg.

What is the regulatory mechanism of AURKC protein activity? 05/21/2022

The activity of AURKC protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKC protein reach its peak expression? 04/09/2022

It reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

How is AURKC protein associated with cancer? 12/19/2021

The abnormal expression of AURKC protein in some cancers is associated with the initiation and progression of tumors. Further studies on the mechanism of action of AURKC protein in cancer may contribute to the development of cancer therapy.

What is the cellular localization of AURKC protein? 06/28/2019

AURKC protein is mainly localized in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

How is AURKC protein associated with reproductive disorders and infertility? 01/11/2019

Mutation or abnormal expression of AURKC protein is associated with reproductive disorders and infertility in both males and females. Studies have found that AURKC gene mutations may lead to abnormal sperm or egg development and dysfunction.

Customer Reviews (3)

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Reviews
06/01/2020

    It is very stable and can be stored and used for a long time.

    12/02/2019

      This price is very reasonable and good value for money.

      03/18/2019

        The activity is very strong and can meet my research needs.

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