Recombinant Human Activin A Receptor Type II-like 1, GST-tagged, Active

• Cat.No.: ACVRL1-238H
• Product Overview: Recombinant human ALK1 (144-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=64 kDa.

Specification

• Cat. No.: ACVRL1-238H
• Description: ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGFβ superfamily. ALK1 functions as a TGFβ type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGFβ signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 144-end.
• Applications: Kinase Assay, Western Blot.
• Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ]
• Synonyms: ACVRL1; activin A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; activin A receptor type II-like 1; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1; serine/threonine-protein kinase receptor R3; EC 2.7.11.30
• Gene ID: 94
• mRNA Refseq: NM_000020
• Protein Refseq: NP_000011
• MIM: 601284
• UniProt ID: P37023
• Chromosome Location: 12q11-q14
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: ATP binding; SMAD binding; activin receptor activity, type I; magnesium ion binding; nucleotide binding; receptor activity; transferase activity; transforming growth factor beta binding