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Recombinant Human MAP2K2, GST-tagged, Active

Cat.No. : MAP2K2-350H
Product Overview : Recombinant full-length human MEK2 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 71 kDa.
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Cat. No. : MAP2K2-350H
Description : MEK2 is the member of MAPK kinase (MAPKK) family of signaling protein kinases. MEK2 is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) and mitogen-activated protein (MAP) kinase upon agonist binding to receptors. MEK2 plays a key role in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathways. Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK2 results in cellular transformation. The ERK/MAP kinase cascade regulates cell growth and differentiation.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : MAP2K2 mitogen-activated protein kinase kinase 2 [ Homo sapiens ]
Synonyms : MAP2K2; mitogen-activated protein kinase kinase 2; MEK2; MKK2; MAPKK2; PRKMK2; FLJ26075; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; mitogen-activated protein kinase kinase 2
Gene ID : 5605
mRNA Refseq : NM_030662
Protein Refseq : NP_109587
MIM : 601263
UniProt ID : P36507
Chromosome Location : 19p13.3
Pathway : Acute myeloid leukemia; B cell receptor signaling pathway; Bladder cancer; Chronic myeloid leukemia; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pathways in cancer; Prion diseases; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway; Thyroid cancer; Toll-like receptor signaling pathway; VEGF signaling pathway; Vascular smooth muscle contraction
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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